{
  "abstract": "INTRODUCTION: The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and plays a key role in sleep–wake regulation. However, evidence linking LC integrity to objective sleep measures in the context of emerging AD pathology remains limited.\n\nMETHODS: Thirty‐nine cognitively unimpaired older adults underwent dedicated LC and neurite orientation dispersion and density imaging at 7T magnetic resonance imaging, actigraphy, and quantification of plasma AD‐related biomarkers. A subsample of 20 individuals also completed at‐home sleep electroencephalogram (EEG) recordings.\n\nRESULTS: Lower LC orientation dispersion index, indicating lower complexity in the arborization of LC neurites, was associated with actigraphy‐ and EEG‐derived measures of shorter and more fragmented sleep. These associations were exacerbated at elevated plasma phosphorylated tau 217 and glial fibrillary acidic protein concentrations.\n\nDISCUSSION: Our findings provide in vivo evidence of the LC's involvement in sleep disruption, and they highlight LC microstructure as a potential marker for identifying individuals at risk for AD‐related sleep disturbances.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg Maastricht University Maastricht the Netherlands",
    "Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA",
    "Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife Boston Massachusetts USA",
    "Department of Neurology University of Toronto Toronto Ontario Canada",
    "Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy, The University of Gothenburg Mölndal Sweden",
    "Banner Alzheimer's Institute and University of Arizona Phoenix Arizona USA",
    "Banner Sun Health Research Institute Sun City Arizona USA",
    "Clinical Memory Research Unit Department of Clinical Sciences Malmö Lund University Lund Sweden",
    "Eli Lilly and Company Gothenburg Sweden",
    "Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden",
    "Department of Neurodegenerative Disease UCL Institute of Neurology, Queen Square London UK",
    "UK Dementia Research Institute at UCL London UK",
    "Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay Hong Kong China",
    "Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA",
    "Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health University of Wisconsin–Madison Madison Wisconsin USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Maxime Van Egroo",
      "orcid": "0000-0002-3142-2623"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuliya Patsyuk"
    },
    {
      "affs": [
        1
      ],
      "name": "Marion Baillet"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Nicholas M. Vogt"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrew S. P. Lim"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Nicholas J. Ashton"
    },
    {
      "affs": [
        7
      ],
      "name": "Shorena Janelidze"
    },
    {
      "affs": [
        4,
        8
      ],
      "name": "Kaj Blennow"
    },
    {
      "affs": [
        7
      ],
      "name": "Oskar Hansson"
    },
    {
      "affs": [
        4,
        9,
        10,
        11,
        12,
        13,
        14
      ],
      "name": "Henrik Zetterberg"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Heidi I. L. Jacobs"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dbax9jtj0cfab.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71964",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736551/",
  "id": "dbax9jtj0cfab",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71964",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7225301312",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71964",
  "pmcid": "PMC13736551",
  "pmid": "42982755",
  "published": "2026-11-04",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/dbax9jtj0cfab.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:58Z",
      "native_id": "PMC13736551",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71964"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Locus coeruleus microstructural integrity and sleep disruption in the context of Alzheimer's disease pathology",
  "title_text": "Locus coeruleus microstructural integrity and sleep disruption in the context of Alzheimer's disease pathology",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:58Z",
  "url": "https://research.draconitic.com/paper/dbax9jtj0cfab",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}