{
  "abstract": "Inflammatory bowel disease (IBD) is an incurable disorder that requires long-term management, which is limited by suboptimal efficacy and systemic toxicity of current treatments. We developed a series of glucocorticoid-derived ionizable lipids and formulated them into lipid nanoparticles (LNPs) for rectal and lesion-localized mRNA delivery. MP2 LNPs, the lead formulation based on a methylprednisolone-derived ionizable lipid, showed a 15-fold higher delivery efficiency in vivo than the FDA approved SM102 LNPs. When loaded with interleukin-35 (IL-35) mRNA, MP2 LNPs (MP2-IL-35) ameliorated colitis in acute and chronic IBD mouse models, as shown by improved clinical scores, preserved colon length, and reduced pro-inflammatory cytokines. In ex vivo human colonic biopsies, MP2 LNPs enabled effective mRNA delivery in immune, epithelial and endothelial cells. Moreover, in biopsies from patients with IBD, MP2-IL-35 LNPs significantly reshaped effector and regulatory T cell subsets. Together, these findings support MP2-IL-35 LNPs as a promising mRNA therapy for IBD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Dinglingge Cao",
      "orcid": "0009-0007-3776-7474"
    },
    {
      "name": "Meng Tian",
      "orcid": "0000-0001-7719-9896"
    },
    {
      "name": "Changyue Yu",
      "orcid": "0000-0003-1308-4269"
    },
    {
      "name": "Yonger Xue",
      "orcid": "0000-0002-6022-2487"
    },
    {
      "name": "Zhengwei Liu",
      "orcid": "0009-0003-5105-6709"
    },
    {
      "name": "Yichen Zhong",
      "orcid": "0000-0003-3652-1257"
    },
    {
      "name": "Xucheng Hou",
      "orcid": "0000-0001-7833-8704"
    },
    {
      "name": "Haoyuan Li"
    },
    {
      "name": "Ya Ying Zheng"
    },
    {
      "name": "Siyu Wang"
    },
    {
      "name": "Michael Tankelevich"
    },
    {
      "name": "Shruti Naik",
      "orcid": "0000-0002-2216-5135"
    },
    {
      "name": "Saurabh Mehandru",
      "orcid": "0000-0001-9781-2969"
    },
    {
      "name": "Yizhou Dong",
      "orcid": "0000-0001-5786-0659"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dbrbj0qrpz6c5.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78302-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737053/",
  "id": "dbrbj0qrpz6c5",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78302-5",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|RNA Interference and Gene Delivery"
    ]
  ],
  "openalex": "W7220864297",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78302-5_reference.pdf",
  "pmcid": "PMC13737053",
  "pmid": "42982860",
  "published": "2026-10-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/dbrbj0qrpz6c5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78302-5",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78302-5"
    },
    {
      "first_seen": "2026-11-09T12:22:21Z",
      "native_id": "PMC13737053",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78302-5"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA Interference and Gene Delivery",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Anti-inflammation lipid nanoparticles enable localized mRNA therapy for inflammatory bowel disease",
  "title_text": "Anti-inflammation lipid nanoparticles enable localized mRNA therapy for inflammatory bowel disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:21Z",
  "url": "https://research.draconitic.com/paper/dbrbj0qrpz6c5",
  "venue": "Nature Communications",
  "versions": []
}