{
  "abstract": "Diabetic bone defects heal poorly due to hyperglycemia-induced impairments in osteogenesis and angiogenesis, which may lead to delayed regeneration if left untreated. To address these challenges, we developed a composite 3D-printed poly(lactic-co-glycolic acid)/hydroxyapatite (HA) scaffold functionalized with the orchestrated release of vascular endothelial growth factor-mimetic peptide (QK) and osteogenic growth peptide (OGP). The unique triphasic release profile of the scaffold was engineered to mimic natural bone-healing cascades: (1) the initial rapid release of QK peptides resulting from degradation of the dextran methacrylate coating initiates angiogenesis, thereby addressing the critical vascular deficiency; (2) the subsequent sustained release of OGP stimulates osteoblast differentiation and bone formation; and (3) the prolonged release of Ca 2+ and PO 4 3− from nano-HA particles supports matrix mineralization and structural integrity. This spatiotemporally coordinated delivery system surpasses conventional single-factor approaches by simultaneously addressing the multiple pathological features of diabetic bone abnormalities. In-vitro and in-vivo evaluations validated the sequential release kinetics of the scaffold that effectively couple vascularization and osteogenesis, establishing a regenerative milieu that mitigates diabetes-impaired healing deficiencies. The coordinated actions of these components not only offer an alternate therapeutic strategy for diabetic bone defects but also hold potential for application in other complex tissue-regeneration scenarios requiring coordinated multicellular responses.",
  "abstract_shown": true,
  "affiliations": [
    "Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Department of Spine Surgery & Innovative Laboratory of Orthopedics, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, China; Department of Orthopedic Department, Jiading District Central Hospital, Shanghai, 201800, China",
    "Department of Spine Surgery & Innovative Laboratory of Orthopedics, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, China",
    "Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China",
    "Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China",
    "Department of Orthopedic, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, 999077, Hong Kong Special Administrative Region of China; Corresponding author. Department of Orthopedic, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.",
    "Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China; Corresponding author. Orthopedic Department & Hubei Sports Medicine Center, Wuhan Fourth Hospital, Wuhan, 430030, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hantao Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yansong Dong"
    },
    {
      "affs": [
        2
      ],
      "name": "Jun Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Zecai Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhen Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuandu Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Yafang Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Weihong Yi"
    },
    {
      "affs": [
        4
      ],
      "name": "Wenzhao Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Qingsong Zhang"
    },
    {
      "name": "Jie Tan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dc0pnt7rpdrz9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.engmed.2026.100163",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2950489926000448",
  "id": "dc0pnt7rpdrz9",
  "issns": [
    "2950-4899"
  ],
  "landing_url": "https://doi.org/10.1016/j.engmed.2026.100163",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R855-855.5"
    ],
    [
      "openalex",
      "2204|Bone Tissue Engineering Materials"
    ]
  ],
  "openalex": "W7212015010",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dc0pnt7rpdrz9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:58Z",
      "native_id": "c9544a2288584ea895d4f8ceb1fc9171",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.engmed.2026.100163"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R855-855.5",
      "subfield": "general"
    }
  ],
  "title": "A 3D-printed composite scaffold with sequential delivery of QK and osteogenic growth peptides promotes diabetic bone regeneration through angiogenic and osteogenic modulation",
  "title_text": "A 3D-printed composite scaffold with sequential delivery of QK and osteogenic growth peptides promotes diabetic bone regeneration through angiogenic and osteogenic modulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:58Z",
  "url": "https://research.draconitic.com/paper/dc0pnt7rpdrz9",
  "venue": "EngMedicine",
  "versions": []
}