{
  "abstract": "甲基苯丙胺（METH）具有高度成瘾性，长期滥用可导致神经毒性。METH诱导的神经毒性及成瘾涉及遗传易感性、表观遗传修饰异常、转录失衡、蛋白质功能紊乱、代谢稳态失调以及微生物及其衍生物紊乱等多个层面。为系统解析上述多层次改变，基因组学鉴定了与METH成瘾易感性相关的关键基因多态性及METH暴露后脑区DNA甲基化等表观遗传改变；转录组学动态刻画了METH处理后相关脑区中突触可塑性、神经炎症通路的差异表达基因谱；蛋白质组学精准定位了METH引起的与突触可塑性相关的功能蛋白表达失调；代谢组学量化了METH诱导的神经递质耗竭和氧化还原失衡；微生物组学则揭示了METH暴露导致肠道菌群紊乱，并通过脑-肠轴介导神经系统损害。本文综述了组学分析技术在METH神经毒性和成瘾研究中的应用现状，以期为阐明METH滥用的致病机制、筛选生物标志物和发掘潜在治疗靶点提供参考。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "丽沙 徐",
      "orcid": "0009-0000-7243-5773"
    },
    {
      "name": "霖 苗"
    },
    {
      "name": "俭 黄",
      "orcid": "0000-0001-9026-789X"
    },
    {
      "name": "娟 李",
      "orcid": "0009-0001-6746-4796"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dcnatg22f8mtr.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2025-0887",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722847/",
  "id": "dcnatg22f8mtr",
  "issns": [
    "1008-9292"
  ],
  "landing_url": "https://doi.org/10.3724/zdxbyxb-2025-0887",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "R749.6"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "2804|Neurotransmitter Receptor Influence on Behavior"
    ]
  ],
  "openalex": "W7201879426",
  "pdf_url": null,
  "pmcid": "PMC13722847",
  "pmid": "42571966",
  "published": "2026-08-07",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/dcnatg22f8mtr.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:35Z",
      "native_id": "PMC13722847",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2025-0887"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neurotransmitter Receptor Influence on Behavior",
      "subfield": "neuroscience"
    }
  ],
  "title": "组学分析技术在甲基苯丙胺诱导的神经毒性和成瘾中的应用进展",
  "title_text": "组学分析技术在甲基苯丙胺诱导的神经毒性和成瘾中的应用进展",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:35Z",
  "url": "https://research.draconitic.com/paper/dcnatg22f8mtr",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}