{
  "abstract": "Notch signaling is a conserved cell-fate pathway that becomes therapeutically important when malignant cells use it to sustain stemness, epithelial plasticity, vascular remodeling, immune escape, and resistance to cytotoxic therapy. Natural products provide a chemically diverse source of Notch modulators, including polyphenols, flavonoids, alkaloids, terpenoids, and related phytochemicals that can influence receptor activation, nuclear Notch signaling, and downstream phenotypes. Their multi-target behavior is attractive in heterogeneous tumors, yet the same compounds often suffer from poor aqueous solubility, rapid metabolism, low systemic exposure, weak tumor accumulation, and formulation instability. Nanomedicine offers a practical route to re-engineer these compounds as therapeutic systems rather than isolated small molecules. Liposomes, polymeric nanoparticles, solid lipid systems, hydrogels, biomimetic carriers, and stimulus-responsive platforms can increase bioavailability, prolong circulation, improve tumor localization, and support co-delivery with chemotherapy, nucleic acids, immunomodulators, or pathway inhibitors. This review summarizes the Notch cascade in cancer, representative natural products that modulate Notch-driven cancer phenotypes, pharmacokinetic barriers that restrict their translation, and nanomedicine strategies that may overcome these barriers. It also discusses active targeting of the Notch/cancer stem cell axis, biomimetic delivery, co-delivery systems for resistance reversal, and translational challenges involving nanotoxicity, manufacturing, advanced models, and systems-level evaluation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Qingmiao Shi"
    },
    {
      "name": "Zhibo Zhang"
    },
    {
      "name": "Xiaonan Geng"
    },
    {
      "name": "Yixin Kang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dct0e0hpr8r2q.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.2022548",
  "fulltext_url": null,
  "id": "dct0e0hpr8r2q",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2022548",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/pharmacology-toxicology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/dct0e0hpr8r2q.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:33Z",
      "native_id": "10.3389/fphar.2026.2022548",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2022548"
    },
    {
      "first_seen": "2026-11-09T12:23:31Z",
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      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2022548/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/pharmacology-toxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Nanomedicine-enabled delivery of natural products targeting the Notch cascade: addressing translational barriers in cancer therapy",
  "title_text": "Nanomedicine-enabled delivery of natural products targeting the Notch cascade: addressing translational barriers in cancer therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/dct0e0hpr8r2q",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}