{
  "abstract": "Objective:: In this study, nuclear magnetic resonance (NMR) spectroscopy was used in prostate tissue to gather novel data on biomarkers that could predict biochemical recurrence in prostate cancer.\n\nMethods:: Prostate tissue cores were collected from individuals who presented to our institution for transrectal biopsy. After acquiring all the spectra using a Bruker Avance III DRX 600 spectrometer, tissue specimens were subjected to routine histology to confirm the presence or absence of prostate cancer. Univariate and multivariate analyses with metabolic and clinical variables were performed to predict biochemical recurrence in men treated for prostate cancer.\n\nResults:: Data were collected from 70 patients treated for prostate cancer, 16 of whom developed biochemical recurrence within 5 years of treatment, with an average time to diagnosed recurrence of 25.68 ± 15.39 months. Metabolites detected in tissue, such as O-phosphoethanolamine, ethanol, succinate, or ascorbate, together with ISUP grades of 4 and 5, formed a predictive model for biochemical recurrence with an area under the curve (AUC) of 0.88, a specificity of 91%, and a negative predictive value (NPV) of 88%.\n\nConclusion:: In prostate cancer patients who have undergone treatment, metabolomic evaluation through HR-MAS can serve as a predictor of biochemical recurrence. Metabolites such as O-phosphoethanolamine, ethanol, succinate, ascorbate, and cysteine are useful in this context. Adding another clinical variable, such as ISUP grades 4 and 5, in prostate histology to these metabolites forms a predictive model capable of predicting biochemical recurrence in prostate cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, University Clinic Hospital of Valencia, INCLIVA, Health Research Institute, University of Valencia Faculty of Medicine and Odontology, Valencia, Spain",
    "Department of Physiology, University of Valencia Faculty of Medicine, Valencia, Spain",
    "Institute for Biomedical Research, Hospital Clinic of Valencia (INCLIVA), Valencia, Spain",
    "Department of Pathology, University of Valencia Faculty of Medicine and Odontology, Valencia, Spain",
    "Research Unit, INCLIVA Health Research Institute, Valencia, Spain",
    "Department of Pathology, University Clinic Hospital of Valencia, INCLIVA, Health Research Institute, University of Valencia Faculty of Medicine and Odontology, Valencia, Spain",
    "Department of Metabolomic, University of Valencia, Valencia, Spain"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jorge Panach-Navarrete",
      "orcid": "0000-0001-5522-339X"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Vannina González-Marrachelli",
      "orcid": "0000-0002-4097-3312"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "José Manuel Morales-Tatay",
      "orcid": "0000-0002-4404-6735"
    },
    {
      "affs": [
        0
      ],
      "name": "Francisco García-Morata",
      "orcid": "0000-0002-4192-5865"
    },
    {
      "affs": [
        5
      ],
      "name": "María Ángeles Sales-Maicas",
      "orcid": "0000-0003-0997-3397"
    },
    {
      "affs": [
        6
      ],
      "name": "Daniel Monleón-Salvado",
      "orcid": "0000-0002-4803-1573"
    },
    {
      "affs": [
        0
      ],
      "name": "José María Martínez Jabaloyas",
      "orcid": "0000-0003-0678-9287"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dcvcnfjy698qe.bib",
  "cited_by": 0,
  "doi": "10.5152/tud.2026.25102",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13747003/",
  "id": "dcvcnfjy698qe",
  "issns": [
    "2980-1478"
  ],
  "landing_url": "https://doi.org/10.5152/tud.2026.25102",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "heading",
      "Urooncology"
    ],
    [
      "openalex",
      "2748|Prostate Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221604092",
  "pdf_url": "https://urologyresearchandpractice.org/index.php/pub/article/download/3738/3713",
  "pmcid": "PMC13747003",
  "pmid": null,
  "published": "2026-10-13",
  "publisher": "AVES",
  "ris": "https://research.draconitic.com/paper/dcvcnfjy698qe.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T12:24:15Z",
      "native_id": "PMC13747003",
      "source": "pmc",
      "url": "https://doi.org/10.5152/tud.2026.25102"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Prostate Cancer Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Metabolic Analysis Using HR-MAS in Prostate Tissue to Predict Biochemical Recurrence in Prostate Cancer",
  "title_text": "Metabolic Analysis Using HR-MAS in Prostate Tissue to Predict Biochemical Recurrence in Prostate Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:23:51Z",
  "url": "https://research.draconitic.com/paper/dcvcnfjy698qe",
  "venue": "Urology Research and Practice",
  "versions": []
}