{
  "abstract": "Introduction\n\nRadical cystectomy (RC) with urinary diversion remains the gold standard for the treatment of muscle invasive tumors. RC is a major surgery associated with a high morbidity rate. Postoperative acute kidney injury (AKI) is associated with severe morbidity and mortality. In this study we attempted to identify risk factors for postoperative AKI in patients undergoing RC.Patients and methods\n\nA multicenter retrospective analysis was conducted among patients treated with radical cystectomy for muscle-invasive bladder cancer between 2015 and 2024. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO), within 90 days of surgery, with the occurrence of 1 of the 3 items: (1) increase in serum creatinine by ≥ 26.5 µmol/L within 48 h; (2) increase in serum creatinine ≥ 1.5-time baseline, which is known or presumed to have occurred within the prior seven days; (3) urine volume < 0.5 ml/kg/h during 6 h, KDIGO score were also recorded. Data were compared between two groups of patients: occurrence of AKI within the first 30 days of the post-operative period (AKI group) or no AKI during this period (no AKI group).Results\n\nWe included 520 patients. The incidence of postoperative AKI was 40.38% (n = 210). Patients with AKI were active smoker (p = 0.03), significantly less often anemic (p = 0.01), had a higher BMI (p = 0.002), preoperative anemia (p = 0.01). Duration of surgery was longer in AKI patients (p < 0.001). AKI patients were more likely to need vasoactive agents (p = 0.04). Independent factors associated with AKI were intraoperative blood loss (OR = 4.8 [95%CI: 3.06-6.43]; p = 0.01), duration of surgery (OR = 3.36 [95%CI: 2.9-11.19]; p = 0.0014); Preoperative anemia (OR = 2.69 [95%CI: 1.06-5.2]; p < 0.001); use of vasoactive agents (OR = 6.36, [95%CI: 6.01-36.87]; p < 0.001). Postoperative AKI was not associated with 2-year mortality (p = 0.71).Conclusion\n\nA significant number of patients experienced AKI after RC. Recognizing pre- and perioperative risk factors can identify patients where close surveillance and early intervention may help minimize renal function decline following RC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, La Rabta Hospital, The Faculty of Medicine of Tunis, University of Tunis Manar, Tunis, Tunisia. chakerkays@gmail.com.",
    "Department of Urology, Habib Bourguiba Hospital, The Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.",
    "Pedagogy Committee of the Faculty of Medicine of Sfax, Physical medecine and rehabilitation Department, Military Hospital, Sfax, Tunisia.",
    "Department of Pathology, La Rabta Hospital, The Faculty of Medicine of Tunis, University of Tunis Manar, Tunis, Tunisia.",
    "Department of Urology, La Rabta Hospital, The Faculty of Medicine of Tunis, University of Tunis Manar, Tunis, Tunisia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kays Chaker",
      "orcid": "0000-0003-0193-3972"
    },
    {
      "affs": [
        1
      ],
      "name": "Ahmed Chaabouni"
    },
    {
      "affs": [
        2
      ],
      "name": "Wafa Elleuch"
    },
    {
      "affs": [
        3
      ],
      "name": "Aida Khadhar"
    },
    {
      "affs": [
        1
      ],
      "name": "Khouloud Ouertani"
    },
    {
      "affs": [
        4
      ],
      "name": "Ali Chakroun"
    },
    {
      "affs": [
        4
      ],
      "name": "Afif Limem"
    },
    {
      "affs": [
        4
      ],
      "name": "Yasmine Laabidi"
    },
    {
      "affs": [
        4
      ],
      "name": "Wassim Ben Chedly"
    },
    {
      "affs": [
        4
      ],
      "name": "Yassine Ouanes"
    },
    {
      "affs": [
        4
      ],
      "name": "Mokhtar Bibi"
    },
    {
      "affs": [
        4
      ],
      "name": "Mahdi Marrak"
    },
    {
      "affs": [
        3
      ],
      "name": "Ines Chelly"
    },
    {
      "affs": [
        1
      ],
      "name": "Mourad Hadj Slimene"
    },
    {
      "affs": [
        4
      ],
      "name": "Yassine Nouira"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dd14csd72cyw0.bib",
  "cited_by": 0,
  "doi": "10.1186/s12894-026-02282-3",
  "fulltext_url": "https://europepmc.org/articles/PMC13689066",
  "id": "dd14csd72cyw0",
  "issns": [
    "1471-2490"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907957",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC870-923"
    ],
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7171438285",
  "pdf_url": "https://europepmc.org/articles/PMC13689066?pdf=render",
  "pmcid": "PMC13689066",
  "pmid": "42907957",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/dd14csd72cyw0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42907957",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907957"
    },
    {
      "first_seen": "2026-10-30T13:46:23Z",
      "native_id": "811aa8522f584abca1e47cd6f6953049",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12894-026-02282-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Predicting acute kidney injury after radical cystectomy for muscle-invasive bladder cancer.",
  "title_text": "Predicting acute kidney injury after radical cystectomy for muscle-invasive bladder cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:23Z",
  "url": "https://research.draconitic.com/paper/dd14csd72cyw0",
  "venue": "BMC urology",
  "versions": []
}