{
  "abstract": "Purpose\n\nPatients undergoing pancreatoduodenectomy for periampullary malignancies are at high nutritional risk. The aim was to characterize longitudinal changes in reported dietary intake, clinical-nutritional biomarkers, and inflammatory-nutritional indices after surgery and contextualize them through cross-sectional comparisons with age- and sex-similar controls.Methods\n\nThis prospective longitudinal cohort included 24 patients and 20 contextual controls. Patients were assessed preoperatively and at 3 and 6 months after discharge; controls were assessed once. Dietary intake was estimated using an adapted food frequency questionnaire (FFQ). FFQ-reported energy surplus was intake minus the 25 kcal/kg/day requirement based on the European Society for Clinical Nutrition and Metabolism (ESPEN). Longitudinal analyses, contextual comparisons, and exploratory adjusted diet-biomarker regressions were performed.Results\n\nOf 24 patients assessed preoperatively, 18 and 16 were reassessed at 3 and 6 months. Median reported energy intake decreased from 2625 to 2011 and 1948 kcal/day, respectively. FFQ-reported energy surplus and intakes of macronutrients, fiber, calcium, iron, and selenium decreased, whereas zinc and vitamins A and E showed no detected longitudinal change. C-reactive protein, ferritin, liver enzymes, and serum vitamin E decreased. Glasgow Prognostic Score (GPS) and C-reactive protein-to-albumin ratio (CAR) decreased, the C-reactive protein-albumin-lymphocyte (CALLY) index increased, and the Prognostic Nutritional Index (PNI) showed no detected longitudinal change. Diet-biomarker associations were limited and inconsistent, although iron intake was positively associated with hemoglobin preoperatively in both adjusted models.Conclusion\n\nDuring the first 6 months after pancreatoduodenectomy, reduced reported dietary intake persisted despite attenuation of systemic inflammation, while biochemical and inflammatory-nutritional indices followed divergent trajectories. These trajectories describe patients alive and available for follow-up.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Clinical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil. marcoas@hcrp.usp.br.",
    "Division of Digestive Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil.",
    "Division of Epidemiology and Statistics, Department of Social Medicine, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil.",
    "Division of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marco Aurélio Ribeiro",
      "orcid": "0000-0003-0995-7258"
    },
    {
      "affs": [
        1
      ],
      "name": "José Sebastião Dos Santos",
      "orcid": "0000-0001-5118-0361"
    },
    {
      "affs": [
        2
      ],
      "name": "Gleici da Silva Castro Perdoná",
      "orcid": "0000-0003-0479-5499"
    },
    {
      "affs": [
        3
      ],
      "name": "Anderson Marliere Navarro",
      "orcid": "0000-0001-9127-3001"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dd2y3t7s58xye.bib",
  "cited_by": 0,
  "doi": "10.1007/s00520-026-11357-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13687123",
  "id": "dd2y3t7s58xye",
  "issns": [
    "0941-4355",
    "1433-7339"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905299",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2916|Clinical Nutrition and Gastroenterology"
    ]
  ],
  "openalex": "W7223119511",
  "pdf_url": "https://europepmc.org/articles/PMC13687123?pdf=render",
  "pmcid": "PMC13687123",
  "pmid": "42905299",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dd2y3t7s58xye.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905299",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905299"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "A prospective cohort study of dietary intake and clinical-nutritional biomarkers in patients with periampullary malignancies undergoing pancreatoduodenectomy in Southeast Brazil.",
  "title_text": "A prospective cohort study of dietary intake and clinical-nutritional biomarkers in patients with periampullary malignancies undergoing pancreatoduodenectomy in Southeast Brazil.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/dd2y3t7s58xye",
  "venue": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
  "versions": []
}