{
  "abstract": "Mitophagy, a critical selective autophagy pathway targeting dysfunctional mitochondria, is involved in cellular homeostasis and quality control under various stressors. During infection, invading pathogens cause mitochondrial abnormalities that trigger mitophagy. Most bacteria and viruses can exploit mitophagy as a pro-pathogenic process to escape host antiviral responses during infection. Emerging evidence suggests that restoring mitophagy is beneficial for mitigating excessive inflammation, such as in sepsis, whereas mitophagy blockade can activate host defense during bacterial and viral infections. Here we review current knowledge on the role of mitophagy in bacterial and viral infections and sepsis, focusing on the mechanisms by which pathogens evade mitophagy or influence pathogenesis through mitophagy during different types of infection. We also highlight the potential beneficial effects of mitophagy modulators, reagents and small molecules against sepsis-induced pathologies and infections. Progress in these areas will expand our knowledge on alleviating pathology, promoting antimicrobial immune responses and maintaining cellular homeostasis, ultimately providing potential preventive and therapeutic strategies against pathogenic infections and inflammation associated with dysregulated mitophagy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea",
    "Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea",
    "Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea",
    "Brain Korea 21 FOUR Project for Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea",
    "Department of Internal Medicine, Division of Hematology/Oncology, Chungnam National University Hospital, Daejeon, Republic of Korea",
    "Department of Microbiology, School of Medicine, Keimyung University, Daegu, Republic of Korea",
    "Biomedical Research Institute, Chungnam National University Hospital, Daejeon, Republic of Korea"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bokeum Jung",
      "orcid": "0009-0003-8264-3228"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Bomi Lee"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Asmita Sapkota"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Taylor Roh",
      "orcid": "0000-0002-6399-1257"
    },
    {
      "affs": [
        4
      ],
      "name": "Wonhyoung Seo"
    },
    {
      "affs": [
        5
      ],
      "name": "Jin Kyung Kim",
      "orcid": "0000-0002-2051-5787"
    },
    {
      "affs": [
        1,
        2,
        6
      ],
      "name": "Eun-Kyeong Jo",
      "orcid": "0000-0001-7191-0587"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dd8gqq92k3rb4.bib",
  "cited_by": 0,
  "doi": "10.1038/s12276-026-01852-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736850/",
  "id": "dd8gqq92k3rb4",
  "issns": [
    "1226-3613",
    "2092-6413"
  ],
  "landing_url": "https://doi.org/10.1038/s12276-026-01852-7",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1307|Autophagy in Disease and Therapy"
    ]
  ],
  "openalex": "W7220461793",
  "pdf_url": "https://www.nature.com/articles/s12276-026-01852-7.pdf",
  "pmcid": "PMC13736850",
  "pmid": "42834108",
  "published": "2026-10-05",
  "publisher": "Korean Society for Biochemistry and Molecular Biology",
  "ris": "https://research.draconitic.com/paper/dd8gqq92k3rb4.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:13Z",
      "native_id": "PMC13736850",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s12276-026-01852-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Autophagy in Disease and Therapy",
      "subfield": "cell-biology"
    }
  ],
  "title": "Mitophagy in pathogenesis and therapeutic implications for infection",
  "title_text": "Mitophagy in pathogenesis and therapeutic implications for infection",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:13Z",
  "url": "https://research.draconitic.com/paper/dd8gqq92k3rb4",
  "venue": "Experimental & Molecular Medicine",
  "versions": []
}