{
  "abstract": "Background: Anti-signal recognition particle (anti-SRP)-positive immune-mediated necrotizing myopathy (IMNM) is a severe subtype of idiopathic inflammatory myopathy, but its long-term prognosis and determinants of adverse outcomes remain insufficiently defined. Because relapse is difficult to ascertain consistently in retrospective studies, IMNM-related readmission may serve as a pragmatic outcome for evaluating subsequent disease course.\n\nObjectives: To estimate the incidence rate of IMNM-related readmission after first discharge and to explore factors associated with readmission in patients with anti-SRP-positive IMNM.\n\nDesign: A single-center retrospective cohort study.\n\nMethods: We included consecutively hospitalized adults with anti-SRP-positive IMNM at West China Hospital between January 2010 and June 2025. Follow-up began at first discharge. The outcome was readmission attributed to IMNM disease activity. The overall incidence rate was calculated per 100 person-years. Stratified incidence analyses were performed according to baseline variables, and factors associated with readmission were explored using LASSO-penalized Cox regression and univariable Cox regression.\n\nResults: Among 131 included patients, 27 experienced IMNM-related readmission during follow-up. The median follow-up was 2.64 years, with a total of 398.53 person-years. The overall incidence rate of IMNM-related readmission was 6.77 per 100 person-years (95% CI, 4.46–9.86). Patients with higher De Ritis ratio (DRR, AST/ALT) had a higher readmission incidence rate than those with lower DRR [9.75 vs 3.28 per 100 person-years; incidence rate ratio (IRR) 2.98, 95% CI 1.24–7.16]. In exploratory univariable Cox regression, DRR was associated with increased readmission risk (HR 3.26, 95% CI 1.49–7.13; P = 0.003).\n\nConclusion: IMNM-related readmission occurred in approximately one-fifth of patients with anti-SRP-positive IMNM during follow-up. Higher DRR was associated with a higher rate of IMNM-related readmission in exploratory analyses. Further prospective studies are needed to clarify the prognostic relevance of DRR and to better characterize the long-term disease course of anti-SRP-positive IMNM.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China",
    "Department of Pathology, West China Hospital, Sichuan University, Chengdu, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Beibei Cui",
      "orcid": "0000-0002-5870-2369"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongjiang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruiting Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziqi Li",
      "orcid": "0009-0003-3838-5727"
    },
    {
      "affs": [
        1
      ],
      "name": "Huijiao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Geng Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Qibing Xie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dddsrsc1e89p5.bib",
  "cited_by": 0,
  "doi": "10.1177/1759720x261488917",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731880/",
  "id": "dddsrsc1e89p5",
  "issns": [
    "1759-720X",
    "1759-7218"
  ],
  "landing_url": "https://doi.org/10.1177/1759720x261488917",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "heading",
      "Precision Medicine in Musculoskeletal Disease"
    ],
    [
      "openalex",
      "2745|Inflammatory Myopathies and Dermatomyositis"
    ]
  ],
  "openalex": "W7213920380",
  "pdf_url": null,
  "pmcid": "PMC13731880",
  "pmid": "42984785",
  "published": "2026-09-21",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/dddsrsc1e89p5.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:59Z",
      "native_id": "PMC13731880",
      "source": "pmc",
      "url": "https://doi.org/10.1177/1759720x261488917"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Inflammatory Myopathies and Dermatomyositis",
      "subfield": "general"
    }
  ],
  "title": "Disease-related readmission in anti-SRP-positive immune-mediated necrotizing myopathy: Incidence and exploratory associated factors in a retrospective cohort study",
  "title_text": "Disease-related readmission in anti-SRP-positive immune-mediated necrotizing myopathy: Incidence and exploratory associated factors in a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:59Z",
  "url": "https://research.draconitic.com/paper/dddsrsc1e89p5",
  "venue": "Therapeutic Advances in Musculoskeletal Disease",
  "versions": []
}