{
  "abstract": "Myelin sheaths comprise compacted layers of membrane wrapped around axons. Each sheath, if 'unwrapped', has a cytoplasm-filled space at its perimeter. Transmission electron microscopy reveals that this space contains microtubules and organelles; however, whether these are developmental remnants or serve a specific function remains unknown. Live imaging of myelinating oligodendrocytes in mice showed microtubule-dependent organelle transport within myelin sheath cytoplasmic spaces. Further, movement of myelin-located peroxisomes was modulated by neuronal electrical activity, in vitro and in vivo. Loss of oligodendroglial KIF21B and/or CNP in vivo led to the apparent stasis of myelin organelles and secondary axon pathology. We, thus, propose the acronym TRAM (transport route across myelin), defining the continuous cytoplasmic network in oligodendrocytes and myelin. This system, comprising the inner and outer tongues and paranodal loops, spans compact myelin and enables transport of metabolites and organelles between the oligodendrocyte soma and the periaxonal space.",
  "abstract_shown": true,
  "affiliations": [
    "School of Infection & Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK",
    "Department of Cell and Developmental Biology, University of Colorado, School of Medicine, Aurora, CO, USA",
    "Dept of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany",
    "School of Life Sciences, University of Nottingham, Nottingham, UK",
    "School of Molecular Biosciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK",
    "Electron Microscopy-City Campus, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany",
    "Faculty of Biology and Psychology, University of Göttingen, Göttingen, Germany",
    "Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany",
    "School of Engineering and Physical Sciences, Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK",
    "Department of Neuropathology, Charité Universitätsmedizin, Berlin, Germany. Nave@mpinat.mpg.de",
    "Dept of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany. Nave@mpinat.mpg.de",
    "Dept of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany. Julia.Edgar@glasgow.ac.uk",
    "School of Infection & Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Julia.Edgar@glasgow.ac.uk"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Katie J. Chapple",
      "orcid": "0000-0003-3653-9860"
    },
    {
      "affs": [
        0
      ],
      "name": "Tabitha R. F. Green"
    },
    {
      "affs": [
        1
      ],
      "name": "Kristen H. Schuster",
      "orcid": "0000-0002-8896-3623"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah Wirth",
      "orcid": "0009-0004-9160-1780"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi-Hsin Chen",
      "orcid": "0009-0006-8297-6104"
    },
    {
      "affs": [
        2
      ],
      "name": "Ulrike C. Gerwig"
    },
    {
      "affs": [
        2
      ],
      "name": "Marie Louise Aicher",
      "orcid": "0009-0009-2408-1427"
    },
    {
      "affs": [
        2
      ],
      "name": "Yeonsu Kim"
    },
    {
      "affs": [
        2,
        0
      ],
      "name": "Lina Komarek",
      "orcid": "0000-0002-2062-457X"
    },
    {
      "affs": [
        3
      ],
      "name": "Angus M. Brown",
      "orcid": "0000-0002-2903-324X"
    },
    {
      "affs": [
        0
      ],
      "name": "Colin L. Crawford",
      "orcid": "0000-0001-7154-5698"
    },
    {
      "affs": [
        0
      ],
      "name": "Rebecca Sherrard Smith",
      "orcid": "0009-0000-7216-0706"
    },
    {
      "affs": [
        4
      ],
      "name": "Young Seok Lee",
      "orcid": "0000-0002-5146-0037"
    },
    {
      "affs": [
        0
      ],
      "name": "Lauren Elaine Black",
      "orcid": "0000-0001-5459-7939"
    },
    {
      "affs": [
        0
      ],
      "name": "Luis Pardo",
      "orcid": "0000-0002-4355-1369"
    },
    {
      "affs": [
        0
      ],
      "name": "Rebecca E. McHugh",
      "orcid": "0000-0003-4664-6125"
    },
    {
      "affs": [
        2
      ],
      "name": "Celia M. Kassmann",
      "orcid": "0000-0003-0993-9455"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Wiebke Möbius",
      "orcid": "0000-0002-2902-7165"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Hauke B. Werner",
      "orcid": "0000-0002-7710-5738"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Ilan Davis",
      "orcid": "0000-0002-5385-3053"
    },
    {
      "affs": [
        7
      ],
      "name": "Matthias Kneussel",
      "orcid": "0000-0003-4900-366X"
    },
    {
      "affs": [
        1
      ],
      "name": "Ethan G. Hughes",
      "orcid": "0000-0003-3243-7429"
    },
    {
      "affs": [
        8
      ],
      "name": "Euan R. Brown",
      "orcid": "0000-0002-5995-834X"
    },
    {
      "affs": [
        2
      ],
      "name": "Sandra Goebbels",
      "orcid": "0000-0001-8343-9972"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Klaus‐Armin Nave",
      "orcid": "0000-0001-8724-9666"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Julia M. Edgar",
      "orcid": "0000-0002-3869-0962"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ddhtc5vhx3mm0.bib",
  "cited_by": 10,
  "doi": "10.1038/s41593-026-02383-0",
  "fulltext_url": null,
  "id": "ddhtc5vhx3mm0",
  "issns": [
    "1097-6256",
    "1546-1726"
  ],
  "landing_url": "https://doi.org/10.1038/s41593-026-02383-0",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2806|Neurogenesis and neuroplasticity mechanisms"
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  "openalex": "W7171969567",
  "pdf_url": null,
  "pmcid": "PMC13533835",
  "pmid": "42538476",
  "published": "2026-07-31",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/ddhtc5vhx3mm0.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
      "native_id": "W7171969567",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41593-026-02383-0"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2806|Neurogenesis and neuroplasticity mechanisms",
      "subfield": "neuroscience"
    }
  ],
  "title": "An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes",
  "title_text": "An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:48Z",
  "url": "https://research.draconitic.com/paper/ddhtc5vhx3mm0",
  "venue": "Nature Neuroscience",
  "versions": []
}