{
  "abstract": "The green synthesis of aluminium nanoparticles (Al-NPs) via aqueous extract of Terminalia chebula was used to evaluate the structural, biological and sensing applications of the synthesized nanoparticles. Nanoparticle development was confirmed by UV–Visible spectroscopy, showing a typical absorption peak at 300 nm. Fourier transform infrared spectroscopy (FTIR) identified key biomolecules involved in reduction and stabilization, including polysaccharides (C–O–C at 1044 cm− 1), proteins/peptides (amide I band at 1660 cm− 1) and phenolic compounds (O–H bending at 1328 cm− 1), with additional bands indicating the presence of alkenes and aromatic groups. Scanning electron microscopy (SEM) revealed irregular, spherical, leaf-like aggregates measuring 30 to 80 nm, while Energy Dispersive X-ray spectroscopy (EDX) established elemental proportion consistent with aluminium oxide, with Carbon, oxygen and aluminium present at 51.9%, 23.9% and 24.5% by weight, respectively. The biological activity of Al-NPs was demonstrated through dose-dependent antiproliferative effects against A549 lung carcinoma cells with an IC₅₀ value of 72.04 µg/mL, assessed via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Biogenic Al-NPs treated cells demonstrated orange-to-red fluorescence, indicates the presence of condensed and fragmented nuclei using Acridine Orange and Ethidium Bromide (AO/EB) assay, indicating apoptosis. The antibacterial efficacy of the biogenic Al-NPs was evaluated using Resazurin Based Microplate assay. The nanoparticles exhibited minimum inhibitory concentration (MIC) values of 1250, 625, 312, and 312 µg/mL and minimum bactericidal concentration (MBC) values of 2500, 1250, 312, and 625 µg/mL against Staphylococcus aureus, Salmonella ebony, Escherichia coli, and Pseudomonas aeruginosa, respectively, demonstrating enhanced activity against Gram-negative bacteria. Furthermore, the Al-NPs exhibited sensitive optical glucose sensing, with UV–Visible spectra showing a linear decrease in plasmonic absorption at 300 nm over glucose concentrations of 1–22 mM. These results highlight the potential of T. chebula mediated Al-NPs as multifunctional nanomaterials for biomedical and biosensing applications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of ENT, Saveetha Medical College and Hospital (SMCH), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University",
    "Department of Biochemistry, Saveetha Medical College and Hospital (SMCH), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University",
    "Department of Dermatology, Saveetha Medical College and Hospital (SMCH), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University",
    "Department of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University",
    "Department of Biotechnology, Persian Gulf Research Institute, Persian Gulf University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
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        0
      ],
      "name": "Shenbhagaraman Ramalingam"
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    {
      "affs": [
        1
      ],
      "name": "Jenefar Sudarson"
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    {
      "affs": [
        1
      ],
      "name": "Archana Behera"
    },
    {
      "affs": [
        1
      ],
      "name": "Mukesh Kumar Dharmalingam Jothinathan"
    },
    {
      "affs": [
        0
      ],
      "name": "Mythileeswari Lakshmikanthan"
    },
    {
      "affs": [
        2
      ],
      "name": "Sakthivel Muthu"
    },
    {
      "affs": [
        3
      ],
      "name": "Maryam Abbasi Tarighat"
    },
    {
      "affs": [
        4
      ],
      "name": "Gholamreza Abdi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ddjvd00me5xwr.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-63168-w",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-63168-w",
  "id": "ddjvd00me5xwr",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-63168-w",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2505|Nanoparticles: synthesis and applications"
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  "openalex": "W7170036196",
  "pdf_url": "https://www.nature.com/articles/s41598-026-63168-w_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/ddjvd00me5xwr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:54Z",
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      "url": "https://doi.org/10.1038/s41598-026-63168-w"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Nanoparticles: synthesis and applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Biogenic aluminium nanoparticles synthesized from Terminalia chebula seed extract: characterization and exploration of their antiproliferative, antimicrobial and biosensing potential",
  "title_text": "Biogenic aluminium nanoparticles synthesized from Terminalia chebula seed extract: characterization and exploration of their antiproliferative, antimicrobial and biosensing potential",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:54Z",
  "url": "https://research.draconitic.com/paper/ddjvd00me5xwr",
  "venue": "Scientific Reports",
  "versions": []
}