{
  "abstract": "The deprotection reaction of N-benzyloxycarbonyl (N-Cbz)-protected amino groups in organic compounds can be efficiently achieved by hydrogenolysis mediated by the sol-gel-entrapped spherical catalyst SiliaCat Pd(0). The heterogeneous catalyst combines high catalytic activity and chemoselectivity with low Pd loading, a nonpyrophoric nature, and excellent reusability. Investigation of the effects of solvent, substrate concentration, Pd loading, temperature, and catalyst particle size revealed that 100 µm spherical SiliaCat Pd(0) provides a favorable balance between rapid reaction kinetics and practical catalyst properties for batch applications. The catalyst was successfully reused over ten consecutive reaction runs, maintaining complete conversion and high isolated yields. A broad substrate scope was demonstrated, with tolerance toward methyl esters, Boc-protected amines, pinacol boronate esters, and an aliphatic bromide, while debromination of an aryl bromide revealed a limitation of the method. Comparison of the 100 µm spherical sol-gel catalyst with several commercial heterogeneous Pd catalysts demonstrates its high catalytic activity and selectivity under mild reaction conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Zeochem Silica Materials, 2500 Boulevard du Parc Technologique, Québec, QC, Canada, G1P 4S6",
    "Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, Palermo, Italy, 90146"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Valerica Pandarus"
    },
    {
      "affs": [
        0
      ],
      "name": "Samuel Cashman-Kadri"
    },
    {
      "affs": [
        1
      ],
      "name": "Rosaria Ciriminna"
    },
    {
      "affs": [
        0
      ],
      "name": "François Béland"
    },
    {
      "affs": [
        1
      ],
      "name": "Mario Pagliaro",
      "orcid": "0000-0002-5096-329X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/de9gxw6debhaj.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010161/v1",
  "fulltext_url": null,
  "id": "de9gxw6debhaj",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010161/v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Asymmetric Hydrogenation and Catalysis"
    ]
  ],
  "openalex": "W7221096256",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010161/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/de9gxw6debhaj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010161",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010161/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Asymmetric Hydrogenation and Catalysis",
      "subfield": "inorganic"
    }
  ],
  "title": "Hydrogenolysis of N-Cbz-Protected Amines Mediated by Spherical SiliaCat Pd(0)",
  "title_text": "Hydrogenolysis of N-Cbz-Protected Amines Mediated by Spherical SiliaCat Pd(0)",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/de9gxw6debhaj",
  "venue": "ChemRxiv",
  "versions": []
}