{
  "abstract": "Background/Objectives: Cognitive impairment in alcohol use disorder (AUD) may reflect alcohol exposure, withdrawal, nutritional disruption, systemic illness, and social vulnerability. We evaluated prioritized human-adult evidence linking nutritional exposures with objective cognition and examined separately whether AUD severity modifies nutrition–cognition associations and whether nutritional disruption mediates the relationship between alcohol exposure and cognitive outcomes. Methods: This structured narrative review used documented multi-database retrieval, pre-access prioritization, full-text adjudication, evidence appraisal, and qualitative sensitivity scenarios. A targeted vitamin B12 update supplemented the baseline corpus. Results: Thiamine had the broadest and most clinically actionable evidence, but biomarker thresholds, optimal cognitive dosing, and independent treatment effects remained uncertain. Evidence for folate, vitamin B12, niacin outside pellagra, other micronutrients, diet, body mass index, and albumin was sparse, mixed, or nonspecific. The targeted B12 evidence was null or contradictory rather than supportive. Cognitive improvement during detoxification could not be separated from abstinence and bundled care. No included study verified causal mediation by nutrition or a formal nutrition-by-severity interaction. Conclusions: Nutritional assessment and prompt treatment of recognized deficiency remain clinically important, but the prioritized retrieved corpus does not justify nutrient-specific causal claims for typical AUD-related cognitive impairment. Longitudinal studies should align repeated nutrition, alcohol exposure, cognition, and function and prespecify interaction and mediation tests.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania",
    "Doctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania",
    "Department of Dentistry, Faculty of Dentistry, ‘Vasile Goldiș’ Western University of Arad, 94–96 Revoluției Blvd., 310025 Arad, Romania",
    "Department of Forensic Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania",
    "Department of Analytical Chemistry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania",
    "Department of Infectious Disease, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania",
    "Department of Bioethics, Deonthology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania",
    "Department of Hygiene, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania",
    "Department Iof-Management and Communication in Dental Medicine, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriela Elena Strete",
      "orcid": "0000-0003-2963-6793"
    },
    {
      "affs": [
        1
      ],
      "name": "Alexandru Mischie",
      "orcid": "0009-0001-7887-2509"
    },
    {
      "affs": [
        0
      ],
      "name": "Lorena Mihaela Grebenisan",
      "orcid": "0000-0003-1745-9427"
    },
    {
      "affs": [
        2
      ],
      "name": "Diana Marian",
      "orcid": "0000-0003-2585-2632"
    },
    {
      "affs": [
        3
      ],
      "name": "Corina Carmen Radu",
      "orcid": "0000-0001-6253-9309"
    },
    {
      "affs": [
        4
      ],
      "name": "Daniela Lucia Muntean"
    },
    {
      "affs": [
        5
      ],
      "name": "Anca Meda Vasiesiu",
      "orcid": "0000-0003-2880-4337"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandru Andrei Ujlaki-Nagi"
    },
    {
      "affs": [
        6
      ],
      "name": "Dora-Mihaela Cîmpian",
      "orcid": "0009-0005-0113-6748"
    },
    {
      "affs": [
        7
      ],
      "name": "Lorand Ferencz",
      "orcid": "0009-0005-3403-5273"
    },
    {
      "affs": [
        8
      ],
      "name": "Ramona Amina Popovici",
      "orcid": "0000-0002-3852-9060"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/deawefnx8013k.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213546",
  "fulltext_url": null,
  "id": "deawefnx8013k",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3546",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Alcoholism and Thiamine Deficiency"
    ]
  ],
  "openalex": "W7223967098",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/deawefnx8013k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:56Z",
      "native_id": "10.3390/nu18213546",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3546"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Alcoholism and Thiamine Deficiency",
      "subfield": "neurology"
    }
  ],
  "title": "Nutritional Exposures and Cognitive Impairment in Alcohol Use Disorder: A Structured Narrative Review of Prioritized Human Evidence",
  "title_text": "Nutritional Exposures and Cognitive Impairment in Alcohol Use Disorder: A Structured Narrative Review of Prioritized Human Evidence",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:56Z",
  "url": "https://research.draconitic.com/paper/deawefnx8013k",
  "venue": "Nutrients",
  "versions": []
}