{
  "abstract": "Through genome mining and metabolomic analysis of the mutant strain CRM005, combined with feature-based molecular networking (FBMN) deduplication, five novel natural cyanogrisides (1–5) were selectively isolated and characterized, alongside six previously reported analogs (6–11). Antiproliferative assays demonstrated that cyanogriside K (8) exhibited potent and selective cytotoxicity against HCT-116 cells, with an IC50 value of 0.70 μM. In an effort to maximize the reutilization of natural product resources, the major aglycone caerulomycin H (11) was utilized to develop a glycosylation system, affording a small panel of nine glycosylated derivatives (13–21). Subsequent antiproliferative evaluations facilitated a preliminary structure–activity relationship analysis focused on variations in the glycosyl groups. Notably, the synthetic compound 13 displayed submicromolar-level activity against the human glioblastoma cell line SF-126 (IC50 0.49 μM), surpassing the activity of doxorubicin (IC50 0.78 μM). These findings position compound 13 as a promising cytotoxic hit derived from a small semisynthetic library and offer preliminary insight into how glycosyl modification impacts antiproliferative activity.",
  "abstract_shown": true,
  "affiliations": [
    "Ocean University of China , , ,",
    "East China University of Science and Technology , , ,",
    "Qingdao Marine Science and Technology Center , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yukang Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingyun Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Linmeng Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Guoliang Zhu",
      "orcid": "0000-0002-6628-8874"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Peng Fu",
      "orcid": "0000-0002-7768-4004"
    },
    {
      "affs": [
        0
      ],
      "name": "Peipei Liu"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Weiming Zhu",
      "orcid": "0000-0002-7591-3264"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ded1zr7zbwxzy.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c04357",
  "fulltext_url": "https://europepmc.org/articles/PMC13689112",
  "id": "ded1zr7zbwxzy",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/62728/5444931/FBMN-Guided-Discovery-of-Cyanogrisides-from-Mutant",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7220651435",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c04357",
  "pmcid": "PMC13689112",
  "pmid": "42923509",
  "published": "2026-10-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/ded1zr7zbwxzy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c04357",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/62728/5444931/FBMN-Guided-Discovery-of-Cyanogrisides-from-Mutant"
    },
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923509",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923509"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "FBMN-Guided Discovery of Cyanogrisides from Mutant Strain CRM005 and Structural Diversification",
  "title_text": "FBMN-Guided Discovery of Cyanogrisides from Mutant Strain CRM005 and Structural Diversification",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/ded1zr7zbwxzy",
  "venue": "ACS Omega",
  "versions": []
}