{
  "abstract": "Introduction Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myopia. Methods In this single-center, double-masked, sham-controlled exploratory trial, 40 children aged 8–12 years were randomized 1:1 to PBM-LED or sham treatment twice daily for 3 months. Primary outcomes were axial length (AL) and cycloplegic spherical equivalent (SE). Results All participants completed follow-up. In eye-specific analyses, the intervention group showed less axial elongation, with significance only in the left eye at 3 months (difference, −0.056 mm; 95% confidence interval, −0.109 to −0.004; P = 0.036). Using participant-level means of both eyes, unadjusted 3-month differences were −0.059 mm for AL (P = 0.061) and 0.244 D for SE (P = 0.092); adjusted differences were not significant. Five eyes across both groups showed a 0.20-logMAR deterioration in uncorrected visual acuity at 3 months, but no eyes showed a 0.20-logMAR or greater decline in best-corrected visual acuity at 1 or 3 months. No serious adverse events or structural retinal abnormalities were observed. Conclusions PBM-LED showed a preliminary short-term treatment signal, but the small sample, unilateral nominal finding, nonsignificant adjusted participant-level analyses, visual-acuity changes, and short follow-up preclude definitive efficacy or long-term safety conclusions. Trial Registration ClinicalTrials.gov identifier NCT07375589.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Eye Disease Prevention and Treatment Center/Eye Hospital of Tongji University, National Clinical Research Center for Eye Diseases",
    "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
    "School of Public Health, Shanghai University of Traditional Chinese Medicine",
    "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University/The Eye Hospital of Wenzhou Medical University (Ningbo Branch)",
    "Faculty of Information Technology, Monash University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuye Duan"
    },
    {
      "affs": [
        1
      ],
      "name": "Ziyi Qi"
    },
    {
      "affs": [
        2
      ],
      "name": "Feiran Yu"
    },
    {
      "affs": [
        3
      ],
      "name": "Kaidi Xiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Haotian Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenglin Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Wei Feng"
    },
    {
      "affs": [
        4
      ],
      "name": "Zongyuan Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Haidong Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xun Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiangui He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dehshvbj9asac.bib",
  "cited_by": 0,
  "doi": "10.1007/s40123-026-01498-8",
  "fulltext_url": "https://doi.org/10.1007/s40123-026-01498-8",
  "id": "dehshvbj9asac",
  "issns": [
    "2193-8245",
    "2193-6528"
  ],
  "landing_url": "https://doi.org/10.1007/s40123-026-01498-8",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RE1-994"
    ],
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      "openalex",
      "2713|Ophthalmology and Visual Impairment Studies"
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  "openalex": "W7211871558",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s40123-026-01498-8.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Adis, Springer Healthcare",
  "ris": "https://research.draconitic.com/paper/dehshvbj9asac.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:44Z",
      "native_id": "42782e8380bd4891aea5de3b6c5b2a9a",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s40123-026-01498-8"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Ophthalmology and Visual Impairment Studies",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial",
  "title_text": "Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:44Z",
  "url": "https://research.draconitic.com/paper/dehshvbj9asac",
  "venue": "Ophthalmology and Therapy",
  "versions": []
}