{
  "abstract": "Cyclic acetals and gem-difluoroalkenes are proven structural motifs in medicinal chemistry, yet their modular incorporation into a densely functionalized hybrid architecture remains an uncharted frontier. Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiao-Tong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Pui Ying Choy",
      "orcid": "0000-0003-2765-0110"
    },
    {
      "affs": [
        0
      ],
      "name": "Chi Wai Cheung",
      "orcid": "0000-0003-4415-0767"
    },
    {
      "affs": [
        0
      ],
      "name": "Fuk Yee Kwong",
      "orcid": "0000-0001-9105-1740"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/deyhfg10x4dzz.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03239",
  "fulltext_url": "https://europepmc.org/articles/PMC13640427",
  "id": "deyhfg10x4dzz",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42917824",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7213999211",
  "pdf_url": "https://europepmc.org/articles/PMC13640427?pdf=render",
  "pmcid": "PMC13640427",
  "pmid": "42917824",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/deyhfg10x4dzz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42917824",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42917824"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal-gem-Difluoroalkenes.",
  "title_text": "Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal-gem-Difluoroalkenes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/deyhfg10x4dzz",
  "venue": "Organic letters",
  "versions": []
}