{
  "abstract": "Genome-wide association studies investigating autoimmune disorders may reveal previously unrecognized regulators of immune cell functions. A Crohn's disease risk allele was associated with increased expression in T lymphocytes of the adapter protein Src kinase-associated phosphoprotein 2 (SKAP2), whose functional role in these cells is unknown. By analyzing T cells from individuals homozygous for either allelic variant or engineered to modulate SKAP2 endogenous levels, we found that SKAP2 promotes T cell adhesion while restraining migration, acting nonredundantly with its homologue SKAP1. Consistent with such functional differences, SKAP1 and SKAP2 displayed distinct activation-induced regulation as well as unique protein interactomes. Prolonged TCR activation triggered caspase-mediated SKAP2 cleavage, leading to the disassembly of its interactome and enabling a migratory program. Together, these findings identify SKAP2 as a genetically regulated modulator of T cell function whose expression and activity control the balance between adhesion and migration.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Research in Biomedicine, Università della Svizzera italiana , Bellinzona, Switzerland.",
    "Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.",
    "Institute of Microbiology, ETH Zürich , Zurich, Switzerland.",
    "INOC - Istituto Nazionale Oncologico Candiolo, IRCCS , Candiolo, Italy.",
    "Department of Oncology, University of Turin, Turin, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mara Cetty Spinella",
      "orcid": "0000-0002-2363-3295"
    },
    {
      "affs": [
        1
      ],
      "name": "Francesco Gualdrini",
      "orcid": "0000-0002-6180-7292"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Leoni",
      "orcid": "0000-0002-4458-1121"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jun Siong Low",
      "orcid": "0000-0002-1775-0778"
    },
    {
      "affs": [
        1
      ],
      "name": "Sara Polletti",
      "orcid": "0000-0002-5433-0502"
    },
    {
      "affs": [
        1
      ],
      "name": "Amy Kenyon",
      "orcid": "0000-0001-9248-576X"
    },
    {
      "affs": [
        0
      ],
      "name": "Samuele Mauri",
      "orcid": "0009-0009-0488-3107"
    },
    {
      "affs": [
        1
      ],
      "name": "Veronica Vallelonga",
      "orcid": "0009-0004-2285-2711"
    },
    {
      "affs": [
        0
      ],
      "name": "Mehrpouya Mostanfar",
      "orcid": "0000-0003-2624-7063"
    },
    {
      "affs": [
        0
      ],
      "name": "Matteo Pecoraro",
      "orcid": "0009-0002-8105-9671"
    },
    {
      "affs": [
        1
      ],
      "name": "Chiara Soriani",
      "orcid": "0000-0003-4363-6597"
    },
    {
      "affs": [
        0
      ],
      "name": "Roberta Marzi",
      "orcid": "0000-0002-3501-4168"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Elena Grassi",
      "orcid": "0000-0003-1066-927X"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabio Bedin",
      "orcid": "0009-0006-4313-7762"
    },
    {
      "affs": [
        0
      ],
      "name": "Elena Foli",
      "orcid": "0009-0003-3916-1653"
    },
    {
      "affs": [
        0
      ],
      "name": "Niccolò Bianchi",
      "orcid": "0000-0001-5605-3425"
    },
    {
      "affs": [
        0
      ],
      "name": "Emina Džafo",
      "orcid": "0000-0001-8276-858X"
    },
    {
      "affs": [
        0
      ],
      "name": "Sandra Jovic",
      "orcid": "0000-0001-6871-8690"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessandro Cuomo",
      "orcid": "0000-0002-9778-7190"
    },
    {
      "affs": [
        1
      ],
      "name": "Simona Rodighiero",
      "orcid": "0000-0003-4236-7823"
    },
    {
      "affs": [
        0
      ],
      "name": "David Jarrossay",
      "orcid": "0000-0002-0924-6395"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Federica Sallusto",
      "orcid": "0000-0003-3750-2752"
    },
    {
      "affs": [
        1
      ],
      "name": "Gioacchino Natoli",
      "orcid": "0000-0003-0711-2411"
    },
    {
      "affs": [
        0
      ],
      "name": "Silvia Monticelli",
      "orcid": "0000-0002-5909-8802"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dezxx9n4ps7se.bib",
  "cited_by": 0,
  "doi": "10.1084/jem.20260507",
  "fulltext_url": "https://europepmc.org/articles/PMC13682646",
  "id": "dezxx9n4ps7se",
  "issns": [
    "0022-1007",
    "1540-9538"
  ],
  "landing_url": "https://europepmc.org/article/MED/42900686",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7223015955",
  "pdf_url": "https://europepmc.org/articles/PMC13682646?pdf=render",
  "pmcid": "PMC13682646",
  "pmid": "42900686",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dezxx9n4ps7se.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42900686",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42900686"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration.",
  "title_text": "A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/dezxx9n4ps7se",
  "venue": "The Journal of experimental medicine",
  "versions": []
}