{
  "abstract": "Background: Most Angolan patients with stroke reach hospital beyond the thrombolysis window, and many deaths occur within 72 h of admission. We investigated routinely recorded variables associated with in-hospital mortality at Hospital do Prenda.\n\nMethods: We conducted a single-centre retrospective cohort study at Hospital do Prenda, a public tertiary hospital in Luanda, from January 2023 to December 2025. The unit of analysis was the hospitalisation episode; four episodes ending in transfer were excluded. Hypertension and type 2 diabetes were extracted from free-text fields using predefined string rules. Univariable analyses used Pearson chi-square, crude odds ratios (OR; 95% CI), and Mann–Whitney tests. Exploratory multivariable logistic regression adjusted for age, sex, year, stroke subtype, recorded comorbidities, and head-CT status. Given the low events-per-variable ratio (~7) and poor calibration in some models, adjusted estimates were considered exploratory associations rather than independent prognostic effects.\n\nResults: Among 479 episodes, 75 patients died (15.7%; 95% CI 12.7–19.2). Median age was 58.5 years among decedents versus 52.0 among survivors ( p = 0.049). Median length of stay was 3 versus 6 days ( p < 0.0001), reflecting early mortality rather than a prognostic exposure. Mortality increased from 6.7% at age 45–54 years to 28.0% at ≥75 years and remained graded after adjustment (≥75 years: adjusted OR 5.92, 95% CI 2.28–15.38; p = 0.0003). Mortality among patients <45 years was also elevated (17.2%; adjusted OR 2.97, 95% CI 1.28–6.87), predominantly among haemorrhagic strokes (22.2% versus 10.8% for ischaemic stroke; age-by-subtype interaction p = 0.0009). Sex, year, stroke subtype, recorded hypertension, and diabetes were not associated with mortality. Absence of head CT showed higher crude mortality (30.0% versus 15.0%; OR 2.42, 95% CI 0.90–6.52). Recorded hypertension prevalence was only 19.8%, indicating substantial under-ascertainment.\n\nConclusion: Older age was the strongest admission-available correlate of in-hospital mortality, while elevated mortality among younger patients was concentrated in haemorrhagic stroke. Under-ascertainment limits interpretation of comorbidities. Absence of stroke-severity, functional-status, ICU, ventilation, and reperfusion data further limits causal or independent prognostic inference.",
  "abstract_shown": true,
  "affiliations": [
    "Neurosurgery Service, Clinica Girassol",
    "Neurosurgery Service, Hospital do Prenda"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sergio Neto"
    },
    {
      "affs": [
        1
      ],
      "name": "Benvindo Cuenda"
    },
    {
      "affs": [
        1
      ],
      "name": "Maria Ngueve Major"
    },
    {
      "affs": [
        1
      ],
      "name": "Jose Kapele"
    },
    {
      "affs": [
        1
      ],
      "name": "Cliofas Pinto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dfb8p4acgmt5s.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1944436",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725788/?tool=EBI",
  "id": "dfb8p4acgmt5s",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1944436/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7222944874",
  "pdf_url": "https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1944436/pdf",
  "pmcid": "PMC13725788",
  "pmid": "42973958",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/dfb8p4acgmt5s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1944436",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1944436/full"
    },
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725788",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725788"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973958",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973958"
    },
    {
      "first_seen": "2026-11-05T12:22:15Z",
      "native_id": "PMC13725788",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fneur.2026.1944436"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Factors associated with in-hospital mortality after stroke at a tertiary hospital in Angola",
  "title_text": "Factors associated with in-hospital mortality after stroke at a tertiary hospital in Angola",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:22:15Z",
  "url": "https://research.draconitic.com/paper/dfb8p4acgmt5s",
  "venue": "Frontiers in Neurology",
  "versions": []
}