{
  "abstract": "Transfusion-related acute lung injury (TRALI) remains a life-threatening complication of blood transfusion, yet the macrophage-neutrophil-NETosis inflammatory amplification mechanism and effective interventions are still incompletely defined. Here, we examined a CD36/Fyn-CXCL-related axis in TRALI and evaluated a ROS-responsive platelet extracellular vesicle biomimetic nanosystem (PEV@SP@EG) as a targeted delivery strategy. In a murine TRALI model, exploratory single-cell transcriptomic analysis showed immune-cell remodeling and linked CD36 expression to M1-like macrophage features. CD36 knockdown or pharmacological inhibition of Fyn/NF-kappaB reduced M1 polarization markers, CXCL production, and ROS generation. Conditioned medium from CD36-overexpressing BMDMs promoted neutrophil migration and NETosis, whereas CXCL-CXCR2 blockade or CD36/Fyn inhibition weakened these responses. PEV@SP@EG showed ROS-triggered drug release and preferential lung enrichment. In vivo , PEV@SP@EG attenuated CD36/Fyn-NF-kappaB-CXCL-related inflammatory signaling, NET formation, and oxidative stress in TRALI lung tissue, with concomitant improvement in lung architecture and gas exchange. These findings support a role for macrophage CD36/Fyn signaling in TRALI-associated macrophage-neutrophil inflammatory crosstalk and suggest that PEV@SP@EG may provide a targeted nanotherapeutic delivery platform for TRALI intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China",
    "Department of Lung Transplantation and Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China",
    "Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China",
    "Tongji University School of Medicine, Shanghai, China",
    "Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Corresponding author. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507, Zhengmin Road, Yangpu District, Shanghai, 200433, China.",
    "Department of Lung Transplantation and Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Corresponding author. Department of Lung Transplantation and Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 1367, Wenyi West Road, Yuhang District, Hangzhou, 310003, Zhejiang Province, China.",
    "Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Clinical Center for Thoracic Surgery Research, Tongji University, Shanghai, China; Corresponding authors. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507, Zhengmin Road, Yangpu District, Shanghai, 200433, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiani Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Ke Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yijiu Ren"
    },
    {
      "affs": [
        2
      ],
      "name": "Fengjing Yang"
    },
    {
      "affs": [
        3
      ],
      "name": "Minjue Shan"
    },
    {
      "affs": [
        3
      ],
      "name": "Yubing Fang"
    },
    {
      "affs": [
        4
      ],
      "name": "Changbo Sun"
    },
    {
      "affs": [
        5
      ],
      "name": "Weili Han"
    },
    {
      "affs": [
        6
      ],
      "name": "Chang Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Xuefei Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dfcrp83esgz2z.bib",
  "cited_by": 1,
  "doi": "10.1016/j.redox.2026.104375",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2213231726003745",
  "id": "dfcrp83esgz2z",
  "issns": [
    "2213-2317"
  ],
  "landing_url": "https://doi.org/10.1016/j.redox.2026.104375",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2403|Neutrophil, Myeloperoxidase and Oxidative Mechanisms"
    ]
  ],
  "openalex": "W7210278450",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dfcrp83esgz2z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:16Z",
      "native_id": "e0de700804e441c58c90d168a4dec48b",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.redox.2026.104375"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Neutrophil, Myeloperoxidase and Oxidative Mechanisms",
      "subfield": "immunology"
    }
  ],
  "title": "A ROS-responsive platelet extracellular vesicle biomimetic nanosystem regulates CD36/Fyn-CXCL-NETosis pathway-mediated immune-inflammatory amplification in the treatment of transfusion-related acute lung injury",
  "title_text": "A ROS-responsive platelet extracellular vesicle biomimetic nanosystem regulates CD36/Fyn-CXCL-NETosis pathway-mediated immune-inflammatory amplification in the treatment of transfusion-related acute lung injury",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:16Z",
  "url": "https://research.draconitic.com/paper/dfcrp83esgz2z",
  "venue": "Redox Biology",
  "versions": []
}