{
  "abstract": "Strain release has long inspired the discovery of unique reactivity, enabling diverse synthetically valuable transformations. Bicyclo[1.1.0]butanes (BCBs), due to their high ring strain, have emerged as versatile building blocks for constructing complex bicyclic architectures. Herein, we report a Lewis acid-catalyzed formal (3 + 3) annulation of BCBs with indolyl alcohols, providing rapid access to indole-fused aza-bicyclo[3.1.1]heptanes. The reaction proceeds under mild conditions, tolerates a broad range of functional groups, and delivers rigid, sp³-rich scaffolds efficiently. Mechanistic studies, including control experiments and computational analysis, indicate a stepwise pathway in which Lewis acid activation of indolyl alcohols generates reactive intermediates, while strain-release of BCBs drives C-C bond formation, followed by C-N bond formation via ring expansion to furnish the fused Aza-bicyclic products.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Indian Institute of Technology, New Delhi, India.",
    "Centre For Nano and Material Sciences, Jain (Deemed-to-be University), Bangalore, Karnataka, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mainak Dey",
      "orcid": "0009-0000-2651-2774"
    },
    {
      "affs": [
        0
      ],
      "name": "Tuhin Subhra Das Mahapatra",
      "orcid": "0009-0003-2281-5120"
    },
    {
      "affs": [
        0
      ],
      "name": "Pragya Sharma",
      "orcid": "0000-0002-5778-3929"
    },
    {
      "affs": [
        1
      ],
      "name": "Manoj V Mane",
      "orcid": "0000-0001-8236-3638"
    },
    {
      "affs": [
        0
      ],
      "name": "Chinmoy Kumar Hazra",
      "orcid": "0000-0001-5968-5305"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dfkyb9fgs1g25.bib",
  "cited_by": 1,
  "doi": "10.1002/advs.78354",
  "fulltext_url": "https://europepmc.org/articles/PMC13676991",
  "id": "dfkyb9fgs1g25",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://europepmc.org/article/MED/42893481",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Synthesis of Indole Derivatives"
    ]
  ],
  "openalex": "W7147249287",
  "pdf_url": "https://europepmc.org/articles/PMC13676991?pdf=render",
  "pmcid": "PMC13676991",
  "pmid": "42893481",
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dfkyb9fgs1g25.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42893481",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42893481"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis of Indole Derivatives",
      "subfield": "organic"
    }
  ],
  "title": "Lewis Acid-Catalyzed Strain-Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole-Fused Aza-Bicyclo[3.1.1]Heptanes.",
  "title_text": "Lewis Acid-Catalyzed Strain-Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole-Fused Aza-Bicyclo[3.1.1]Heptanes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/dfkyb9fgs1g25",
  "venue": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
  "versions": []
}