{
  "abstract": "Background: The MAGIC‐D index was originally developed to predict outcomes in advanced biliary tract cancer (BTC) patients receiving durvalumab‐gemcitabine‐cisplatin (Durva‐Gem‐Cis). This study aimed to assess the efficacy and safety of various durvalumab‐chemotherapy regimens for unresectable BTC patients and the broader applicability of the MAGIC‐D index.\n\nMethods: This study retrospectively recruited unresectable BTC patients receiving durvalumab‐chemotherapy from 2021 to 2024. Overall survival (OS) and progression‐free survival (PFS) were assessed, and patients were risk‐stratified using the MAGIC‐D index.\n\nResults: A total of 89 patients were included in the analysis. Between the Durva‐Gem‐Cis group and the durvalumab plus other chemotherapy regimens (Durva‐Other Regimens) group, the median OS (12.9 vs. 13.9 months) and PFS (5.5 vs. 6.2 months) were comparable. Patients were risk‐stratified into three risk groups (median OS: 21.0, 12.9, 12.4 months for the low‐, intermediate‐, and high‐risk groups, respectively; p = 0.002) using the MAGIC‐D index, which achieved a concordance index (C‐index) of 0.637. The Cox regression analysis showed serum CA 19‐9 level, high Ki67 expression and the MAGIC‐D index were related to OS. An exploratory model named the modified MAGIC‐D index, incorporating Ki67 and CA 19‐9 into the MAGIC‐D index, showed promising discrimination of survival among risk groups (25.0 vs. 12.9 vs. 9.1 months, p < 0.001) with a C‐index of 0.709.\n\nConclusion: Durvalumab plus different chemotherapy regimens achieves comparable outcomes in the treatment of unresectable BTC. Incorporating Ki67 and CA 19‐9 into the MAGIC‐D index may enhance risk stratification, but external validation in larger independent cohorts is required before clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hepato‐Pancreato‐Biliary Surgery, Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan Hubei China",
    "Hubei Key Laboratory of Hepato‐Pancreato‐Biliary Diseases, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China",
    "Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation Chinese Academy of Medical Sciences Wuhan China",
    "Nursing Department Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology Wuhan Hubei China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Tianao Zhan",
      "orcid": "0009-0006-4365-8218"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Hongwei Huang",
      "orcid": "0009-0001-9741-5901"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Juncheng Zhan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Feng Xia",
      "orcid": "0000-0001-8826-6310"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Tianyin Shao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xinkang Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jun Shen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xingbin Xu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yawei Fan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qi Cheng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dfskc3mfx221q.bib",
  "cited_by": 0,
  "doi": "10.1002/cam4.72254",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732815/",
  "id": "dfskc3mfx221q",
  "issns": [
    "2045-7634"
  ],
  "landing_url": "https://doi.org/10.1002/cam4.72254",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2746|Cholangiocarcinoma and Gallbladder Cancer Studies"
    ]
  ],
  "openalex": "W7225268553",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.72254",
  "pmcid": "PMC13732815",
  "pmid": "42979979",
  "published": "2026-11-04",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/dfskc3mfx221q.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:43Z",
      "native_id": "PMC13732815",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cam4.72254"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cholangiocarcinoma and Gallbladder Cancer Studies",
      "subfield": "surgery"
    }
  ],
  "title": "Real‐World Validation of the MAGIC‐D Index in Unresectable Biliary Tract Cancer Treated With Durvalumab Plus Chemotherapy",
  "title_text": "Real‐World Validation of the MAGIC‐D Index in Unresectable Biliary Tract Cancer Treated With Durvalumab Plus Chemotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:43Z",
  "url": "https://research.draconitic.com/paper/dfskc3mfx221q",
  "venue": "Cancer Medicine",
  "versions": []
}