{
  "abstract": "目的探究TLR4/NF-κB信号通路在多囊卵巢综合征（PCOS）慢性低度炎症中的作用及分子机制。方法收集2023年1月至2023年11月吉林大学中日联谊医院生殖医学中心体外受精（IVF）助孕的PCOS组与对照组患者卵泡液颗粒细胞，检测TLR4、NF-κB、NLRP3、IL-1β mRNA表达；建立PCOS大鼠模型，观察动情周期及卵巢形态，检测卵巢组织上述基因表达；以人卵巢颗粒细胞（KGN）为PCOS颗粒细胞模型，加入脂多糖（LPS）、脱氢表雄酮（DHEA）检测细胞增殖活力，再分别联合TLR4抑制剂瑞沙托维（TAK242）、雄激素受体抑制剂氟他胺（F）干预，检测上述基因表达结果。结果PCOS患者颗粒细胞及PCOS大鼠卵巢组织中TLR4、NF-κB、NLRP3、IL-1β mRNA表达均显著高于对照组（P<0.05）；LPS、DHEA可降低KGN细胞增殖活力，经LPS、DHEA处理后KGN细胞炎症相关基因表达显著升高（P<0.05），LPS联合TAK242组、DHEA联合F组、DHEA联合TAK242组干预后细胞活力显著恢复（P<0.05），上述基因表达显著降低（P<0.05）。结论TLR4/NF-κB信号通路与高雄激素共同参与PCOS慢性低度炎症发病过程。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "李懿霖"
    },
    {
      "name": "金明明"
    },
    {
      "name": "范明慧"
    },
    {
      "name": "盛敏佳"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dg0a18f9mr89z.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.019",
  "id": "dg0a18f9mr89z",
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  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/dg0a18f9mr89z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:47Z",
      "native_id": "c545970d584d4a06b559307df2328633",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.019"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "TLR4/NF-κB信号通路在多囊卵巢综合征慢性低度炎症中的作用及机制研究",
  "title_text": "TLR4/NF-κB信号通路在多囊卵巢综合征慢性低度炎症中的作用及机制研究",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:47Z",
  "url": "https://research.draconitic.com/paper/dg0a18f9mr89z",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}