{
  "abstract": "Pulmonary recurrence in endometrial cancer is generally regarded as a manifestation of systemic disease and is primarily managed with systemic therapy. However, the clinical significance of lung-confined recurrent endometrial cancer and the role of pulmonary metastasectomy remain uncertain. To evaluate the long-term oncologic outcomes of pulmonary metastasectomy in patients with lung-confined recurrent endometrial cancer and to explore whether lung-confined recurrence represents a clinically distinct pattern of recurrence. This retrospective single-institution case series included consecutive patients with lung-confined recurrent endometrial cancer who underwent pulmonary metastasectomy between January 2005 and July 2026. Clinicopathological characteristics, long-term oncologic outcomes, and perioperative outcomes were evaluated. Six patients underwent pulmonary metastasectomy for lung-confined recurrent endometrial cancer. The median interval from primary surgery to first pulmonary recurrence was 45.5 months (range, 19-227 months). Complete (R0) pulmonary resection was achieved in all patients without severe surgery-related adverse events. During a median follow-up of 103.5 months (range, 47-250 months) from primary surgery, all 6 patients remained alive, and 5 of 6 achieved durable disease-free status. Following the first pulmonary metastasectomy, 1 patient developed subsequent lung-confined recurrence and underwent repeat pulmonary metastasectomy, achieving additional long-term disease control. Notably, the 2 patients with synchronous bilateral pulmonary metastases also achieved durable disease-free survival following complete staged bilateral resection. Pulmonary metastasectomy may provide durable long-term disease control in carefully selected patients with lung-confined recurrent endometrial cancer. Recognition of lung-confined recurrent endometrial cancer as a clinically distinct pattern of recurrence may support a shift from routine systemic therapy alone toward a more individualized multidisciplinary treatment strategy incorporating pulmonary metastasectomy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto City, Kumamoto, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Minami Kawanaka"
    },
    {
      "affs": [
        0
      ],
      "name": "Akiho Nishimura"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Motohara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dgpsmpdn5dr6b.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xagr.2026.100705",
  "fulltext_url": "https://europepmc.org/articles/PMC13743513",
  "id": "dgpsmpdn5dr6b",
  "issns": [
    "2666-5778"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999453",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7220915023",
  "pdf_url": "https://europepmc.org/articles/PMC13743513?pdf=render",
  "pmcid": "PMC13743513",
  "pmid": "42999453",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dgpsmpdn5dr6b.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42999453",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999453"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Long-term oncologic outcomes of pulmonary metastasectomy for lung-confined recurrent endometrial cancer: a single-institution case series.",
  "title_text": "Long-term oncologic outcomes of pulmonary metastasectomy for lung-confined recurrent endometrial cancer: a single-institution case series.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/dgpsmpdn5dr6b",
  "venue": "AJOG global reports",
  "versions": []
}