{
  "abstract": "Structural comparison of nucleic acids, particularly RNA, is critical for understanding evolutionary and functional relationships beyond sequence similarity, yet efficient tools for large-scale 3D structure search and alignment remain scarce. We extend GTalign to support nucleic acid structures, enabling unified, high-performance alignment across macromolecules. Benchmarking on diverse nucleic acid datasets demonstrates improved alignment accuracy and substantially lower runtimes compared to existing methods. GTalign thus provides a scalable solution for nucleic acid structure comparison and database search. Availability and Implementation: https://github.com/minmarg/gtalign_alpha",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Biotechnology, Vilnius University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. Margelevicius"
    },
    {
      "name": "S. Rana"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dh3jnhkyjcb63.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.06.01.729228",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2.full",
  "id": "dh3jnhkyjcb63",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7163218182",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dh3jnhkyjcb63.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:41Z",
      "native_id": "10.64898/2026.06.01.729228",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.06.01.729228v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "Nucleic acid 3D structure search and alignment with GTalign",
  "title_text": "Nucleic acid 3D structure search and alignment with GTalign",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:41Z",
  "url": "https://research.draconitic.com/paper/dh3jnhkyjcb63",
  "venue": "bioRxiv",
  "versions": []
}