{
  "abstract": "Neuronal activation drives activity-dependent gene expression that underlies experience-associated synaptic modifications, learning and memory. Here we show that the histone variant CENP-A, best known for specifying centromere identity, is dynamically regulated by synaptic activity at both the RNA and protein levels in postmitotic neurons. Neuronal activation increases a non-centromeric nuclear pool of CENP-A while leaving centromeric CENP-A levels unchanged. Downregulation of CENP-A selectively reduces the activity-associated non-centromeric pool, impairs activity-dependent induction of immediate-early genes such as FOS and ARC, and disrupts hippocampus-dependent learning and memory. Furthermore, we find that activity-dependent neuronal responses in human embryonic stem cell-derived forebrain organoids similarly require CENP-A. Our results reveal a mitosis-independent, conserved role of CENP-A for driving plasticity in mammalian neurons.",
  "abstract_shown": true,
  "affiliations": [
    "University of Zurich"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "A. Stankovic"
    },
    {
      "name": "D. Gonzalez-Bohorquez"
    },
    {
      "name": "I. Mallona"
    },
    {
      "name": "M. Quiniou"
    },
    {
      "name": "B. Jaeger"
    },
    {
      "name": "V. Korobeynyk"
    },
    {
      "name": "L. Brandi"
    },
    {
      "name": "S. Guenther"
    },
    {
      "name": "A. Ruenker"
    },
    {
      "name": "A. Garthe"
    },
    {
      "name": "N. Cruz Ochoa"
    },
    {
      "name": "C. Foldy"
    },
    {
      "name": "S. Furlan"
    },
    {
      "name": "G. Kempermann"
    },
    {
      "name": "M. D. Robinson"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Jessberger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dh75vpms98gsq.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.07.16.738894",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.07.16.738894v2.full",
  "id": "dh75vpms98gsq",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.07.16.738894v2",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
  ],
  "openalex": "W7169878058",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.07.16.738894v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dh75vpms98gsq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:42Z",
      "native_id": "10.64898/2026.07.16.738894",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.07.16.738894v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Co-option of CENP-A for activity-induced neuronal plasticity",
  "title_text": "Co-option of CENP-A for activity-induced neuronal plasticity",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:42Z",
  "url": "https://research.draconitic.com/paper/dh75vpms98gsq",
  "venue": "bioRxiv",
  "versions": []
}