{
  "abstract": "CONTEXT: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women, but its true burden remains underestimated due to diagnostic variability and underreporting. OBJECTIVE: To estimate the morbidities in reproductive-age women identified with a diagnosis of PCOS in the French national health data system. METHODS: We conducted a retrospective cohort study using the French national health data system (SNDS) to identify reproductive-age women (18-43 years) diagnosed with PCOS (ICD-10 code E28.2) between 2014 and 2022. Morbidity data were assessed in 2022 and compared with an age-matched control group of women without PCOS in the same year. Specific comorbidities were identified using a set of algorithms applied to the system's data and based on both ICD-10 codes and medical acts and drug use. Logistic regression models were used to compare comorbidity rates, with odds ratios adjusted for age and social deprivation. RESULTS: We identified 21,144 women with PCOS in the health data system. Median age was 35 years [IQR: 29-39]. Compared with the general female population, women with PCOS had significantly higher rates of infertility (adjusted odds ratio (aOR)=24.35), gestational diabetes (aOR=1.64), type 2 diabetes (aOR 14.71), pulmonary embolism (aOR=2.04), arterial hypertension (aOR 5.86), acute stroke (aOR= 2.39), cardioneurovascular disease (aOR 2.12) and psychiatric disorders (aOR=1.66). CONCLUSIONS: Given the high morbidity among women identified with PCOS on ICD-10 code E28.2, improved diagnostic algorithms are needed to better identify PCOS cases in health databases and assess their public health implications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Blandine Courbiere"
    },
    {
      "name": "Eugénie Micolon"
    },
    {
      "name": "Appoline Zimmermann"
    },
    {
      "name": "Pascal Auquier"
    },
    {
      "name": "Julie Berbis"
    },
    {
      "name": "Sandrine Loubière"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dhgqt0wptk51p.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ando.2026.102598",
  "fulltext_url": null,
  "id": "dhgqt0wptk51p",
  "issns": [
    "0003-4266",
    "2213-3941"
  ],
  "landing_url": "https://hal.science/hal-05828582v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sde"
    ],
    [
      "hal",
      "1.sde.be"
    ],
    [
      "openalex",
      "2743|Ovarian function and disorders"
    ]
  ],
  "openalex": "W7168920899",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0003426626001198/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Société française d'endocrinologie [1939-....]",
  "ris": "https://research.draconitic.com/paper/dhgqt0wptk51p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05828582",
      "source": "hal",
      "url": "https://hal.science/hal-05828582v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sde.be",
      "subfield": "ecology"
    },
    {
      "field": "earth",
      "origin": "hal:0.sde",
      "subfield": "environmental-science"
    }
  ],
  "title": "The tip of the iceberg: Morbidity in polycystic ovary syndrome in reproductive-age women",
  "title_text": "The tip of the iceberg: Morbidity in polycystic ovary syndrome in reproductive-age women",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/dhgqt0wptk51p",
  "venue": "Annales d'Endocrinologie = Annals of Endocrinology",
  "versions": []
}