{
  "abstract": "Gametogenesis rejuvenates the cellular lineage and excludes senescence-associated factors from gametes. In Saccharomyces cerevisiae , this involves sequestration of nuclear constituents into the Gametogenesis Uninherited Nuclear Compartment (GUNC), which is excluded from gametes. Here we identify the conserved mitochondrial import receptor Tom70 as a key regulator of GUNC-mediated exclusion. Loss of TOM70 disrupts the sequestration of nuclear pore complexes, but not senescence-associated aggregates and nucleolar components, into the GUNC. Tom70’s role appears independent of its canonical function in mitochondrial import and instead reflects a meiosis-specific requirement for mitochondria-nuclear envelope tethering. During meiosis II, Tom70 concentrates around the GUNC, where it recruits the nuclear envelope tethering protein Cnm1. Loss of CNM1 partially phenocopies tom70 ∆, consistent with parallel tethering interactions. These findings uncover a previously unrecognized organelle contact-dependent pathway that remodels the nuclear envelope to support selective nuclear inheritance. More broadly, they highlight how organelle contacts integrate with nuclear quality control to safeguard gamete integrity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Cyrus T. Ruediger"
    },
    {
      "name": "Benjamin S. Styler",
      "orcid": "0000-0002-0458-8230"
    },
    {
      "name": "Eric M. Sawyer",
      "orcid": "0000-0003-1160-3838"
    },
    {
      "name": "Silvan Spiri",
      "orcid": "0000-0002-7124-3056"
    },
    {
      "name": "Grant A. King"
    },
    {
      "name": "Madison E. Walsh"
    },
    {
      "name": "Gloria A. Brar",
      "orcid": "0000-0002-8560-9581"
    },
    {
      "name": "Danielle M. Jorgens",
      "orcid": "0000-0002-7143-0118"
    },
    {
      "name": "Elçin Ünal",
      "orcid": "0000-0002-6768-609X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dhphem7n6x8tq.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78562-1",
  "fulltext_url": null,
  "id": "dhphem7n6x8tq",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78562-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Nuclear Structure and Function"
    ]
  ],
  "openalex": "W7223311249",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78562-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/dhphem7n6x8tq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78562-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78562-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Nuclear Structure and Function",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Tom70–mediated mitochondria–nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis",
  "title_text": "Tom70–mediated mitochondria–nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/dhphem7n6x8tq",
  "venue": "Nature Communications",
  "versions": []
}