{
  "abstract": "Introduction Macular leakage (ML) is a biomarker of disease activity and, in retinal vein occlusion (RVO), is associated with poor vision outcomes. Faricimab, a dual angiopoietin-2 (Ang-2)/vascular endothelial growth factor (VEGF)-A inhibitor, has demonstrated efficacy and durability in RVO. This post hoc analysis of BALATON/COMINO examined the association between week 24 ML resolution and extended faricimab dosing intervals and vision outcomes achieved at week 68 in patients with RVO. Methods BALATON and COMINO (NCT04740905/NCT04740931) were identically designed, phase 3, randomized trials that evaluated the efficacy and safety of faricimab in patients with branch or central/hemiretinal RVO, respectively. Patients initially received faricimab 6 mg every 4 weeks (Q4W) or aflibercept 2 mg Q4W; then from weeks 24–72, all patients received faricimab 6 mg up to Q16W according to a modified treat-and-extend regimen. This analysis included patients who remained in the study at week 68 and had a fluorescein angiography ML reading at week 24. Results Among 989 patients, 502 had ML resolution (≤ 1 mm2) and 143 had high ML (≥ 10 mm2) at week 24. The proportion of patients who achieved ≥ Q12W faricimab dosing at week 68 was higher among those with ML resolution at week 24 versus those with high ML at week 24 (56.1% vs 38.0%, p = 0.0001). The odds of patients receiving ≥ Q12W faricimab dosing at week 68 were higher among those with ML resolution than among those with high ML at week 24 (odds ratio 2.46, p < 0.001). Patients with ML resolution experienced greater vision gains at week 68 versus patients with high ML at week 24 (18.8 vs 15.0 letters, p = 0.0036). Conclusions ML resolution at week 24 was associated with extended faricimab dosing intervals and improved vision at week 68 in patients with RVO in the BALATON/COMINO clinical trials. ClinicalTrials.gov Identifiers NCT04740905, NCT04740931. Graphical Abstract",
  "abstract_shown": true,
  "affiliations": [
    "Ophthalmology Department, London North West University Healthcare, NHS Trust, Central Middlesex Hospital",
    "University of Illinois at Chicago",
    "Strathfield Retina Clinic",
    "Department of Ophthalmology, Tokyo Medical University Hachioji Medical Center",
    "Retina Associates of Florida",
    "School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University",
    "Everest Clinical Research",
    "Genentech, Inc.",
    "F. Hoffmann-La Roche Ltd.",
    "The Advanced Retina Institute"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Christiana Dinah"
    },
    {
      "affs": [
        1
      ],
      "name": "Harit K. Bhatt"
    },
    {
      "affs": [
        2
      ],
      "name": "Hemal Mehta"
    },
    {
      "affs": [
        3
      ],
      "name": "Masahiko Shimura"
    },
    {
      "affs": [
        4
      ],
      "name": "Ivan J. Suner"
    },
    {
      "affs": [
        5
      ],
      "name": "Xun Xu"
    },
    {
      "affs": [
        6
      ],
      "name": "Nicholas Dagincourt"
    },
    {
      "affs": [
        7
      ],
      "name": "Liliana P. Paris"
    },
    {
      "affs": [
        8
      ],
      "name": "Joern Schweitzer"
    },
    {
      "affs": [
        9
      ],
      "name": "Carl J. Danzig"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dhrjdt0bsn72s.bib",
  "cited_by": 0,
  "doi": "10.1007/s40123-026-01489-9",
  "fulltext_url": "https://doi.org/10.1007/s40123-026-01489-9",
  "id": "dhrjdt0bsn72s",
  "issns": [
    "2193-8245",
    "2193-6528"
  ],
  "landing_url": "https://doi.org/10.1007/s40123-026-01489-9",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RE1-994"
    ],
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ]
  ],
  "openalex": "W7213453258",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s40123-026-01489-9.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Adis, Springer Healthcare",
  "ris": "https://research.draconitic.com/paper/dhrjdt0bsn72s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:48Z",
      "native_id": "c5be30fea1bf4036b729af44f01c1a58",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s40123-026-01489-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Retinal Diseases and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Early Macular Leakage Resolution Is Associated with Extended Faricimab Dosing in Retinal Vein Occlusion: A BALATON/COMINO Post Hoc Analysis",
  "title_text": "Early Macular Leakage Resolution Is Associated with Extended Faricimab Dosing in Retinal Vein Occlusion: A BALATON/COMINO Post Hoc Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:48Z",
  "url": "https://research.draconitic.com/paper/dhrjdt0bsn72s",
  "venue": "Ophthalmology and Therapy",
  "versions": []
}