{
  "abstract": "Background: Recurrence after atrial fibrillation (AF) ablation remains difficult to predict. Circulating microRNAs may reflect molecular substrates not captured by established predictors. We mapped recurrence-specific evidence and identified priorities for prospective validation. Methods: Six databases were searched from inception through 29 August 2026 for adult AF ablation cohorts measuring circulating microRNAs before or around ablation and reporting atrial tachyarrhythmia recurrence. Recurrence-specific reports were assessed with the Quality in Prognosis Studies (QUIPS) tool. A post hoc candidate-centered framework required direct recurrence evidence in at least two analytically distinct samples and support in at least one additional clinical, mechanistic, or analytical domain. Candidate-specific certainty was evaluated with the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. Results: Thirty-five publications represented 29 linked programs; 26 recurrence-specific reports represented 25 independent cohorts (3309 enrolled; 3205 analyzed), and nine publications provided longitudinal context. Six microRNAs were identified as priorities for prospective validation: miR-21-5p, miR-150-5p, miR-29b-3p, miR-451a, miR-10b-5p, and miR-320a. Their evidence differed in mature-arm identity, matrix, sampling compartment, assay scale, biological source, and mechanistic support. Candidate-specific certainty was very low. Conclusions: The evidence supports candidate-specific prospective validation rather than a uniform circulating-microRNA class effect. Standardized preanalytics, mature-arm and carrier attribution, locked assays, and multicenter incremental-prediction studies are required before clinical utility can be established.",
  "abstract_shown": true,
  "affiliations": [
    "Internal Medicine Department, Faculty of Medicine, Federal University of Goiás, Goiânia 74690-900, Goiás, Brazil",
    "School of Medicine, Pontifical Catholic University of Goiás, Goiânia 74605-010, Goiás, Brazil",
    "Postgraduate Program in Genetics, Pontifical Catholic University of Goiás, Goiânia 74605-010, Goiás, Brazil"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Antônio da Silva Menezes",
      "orcid": "0000-0003-1751-5206"
    },
    {
      "affs": [
        0
      ],
      "name": "Arthur de Sousa Silva",
      "orcid": "0009-0002-5243-1112"
    },
    {
      "affs": [
        0
      ],
      "name": "Alcir Júnior de Paula Nunes Meneses"
    },
    {
      "affs": [
        1
      ],
      "name": "Annelyse Vitória Souza Barbosa"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Aparecido Divino da Cruz",
      "orcid": "0000-0003-0753-3814"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dj3kw0b872szf.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16111590",
  "fulltext_url": null,
  "id": "dj3kw0b872szf",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/11/1590",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/dj3kw0b872szf.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T00:23:55Z",
      "native_id": "10.3390/biom16111590",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/11/1590"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:2218-273X",
      "subfield": "general"
    }
  ],
  "title": "Circulating MicroRNAs as Molecular Biomarkers of Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Candidate-Centered Evidence Map",
  "title_text": "Circulating MicroRNAs as Molecular Biomarkers of Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Candidate-Centered Evidence Map",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:50Z",
  "url": "https://research.draconitic.com/paper/dj3kw0b872szf",
  "venue": "Biomolecules",
  "versions": []
}