{ "abstract": "Background\n\nCangrelor, a fast-acting intravenous P2Y12 receptor inhibitor, is increasingly used during mechanical thrombectomy for acute ischemic stroke to treat or prevent thrombotic complications. While effective, its use may increase the risk of hemorrhagic transformation (HT). We investigated clinical, imaging, and procedural predictors of HT in this specific patient population.Methods\n\nWe performed a retrospective post hoc single-center study including 101 patients with acute ischemic stroke treated with intravenous cangrelor initiated directly after mechanical thrombectomy and continued for 12 hours between January 2021 and June 2024. Univariate and multivariable logistic regression models were used to assess associations between HT and clinical, radiological, and procedural factors.Results\n\nAmong the 101 patients included, 25 (24.7%) developed HT, and 9 (8.9%) experienced symptomatic intracerebral hemorrhage. In multivariable analysis, baseline blood glucose (adjusted odds ratio, 6.51 [95% CI, 1.35-31.4]; P=0.02), leukocytosis (adjusted odds ratio, 1.18 [95% CI, 1.00-1.38]; P=0.047), and subarachnoid hemorrhage on postmechanical thrombectomy cone-beam computed tomography (adjusted odds ratio, 16.60 [95% CI, 2.97-92.8]; P=0.0014) were independent predictors of HT. Contrast enhancement was associated with HT in univariate analysis but did not remain significant after adjustment.Conclusions\n\nBaseline blood glucose, leukocytosis, and isolated subarachnoid hemorrhage on postmechanical thrombectomy cone-beam computed tomography emerged as independent predictors of HT. Identifying high-risk patients using readily available clinical and imaging markers may support individualized antiplatelet strategies and help reduce hemorrhagic complications during cangrelor treatment.Registration\n\nURL: https://www.clinicaltrials.gov; Unique identifier: NCT03776877.", "abstract_shown": true, "affiliations": [ "Interventional Neuroradiology Department (A.G., A.F.v.S., B.M., M.P., R.B., S.E., W.B., A.A.R., H.R., S.S., E.R., H.B., M.M., J.-P.D., F.D.), Rothschild Foundation Hospital, Paris, France.", "Interventional Neuroradiology Department (A.G.), Pierre Wertheimer Hospital, Bron, France.", "CREATIS Laboratory, INSERM U1294, Claude Bernard Lyon I University, Villeurbanne, France (A.G., A.B.S.).", "Neurology Department, Foch Hospital, Suresnes, France (D.W.-L.).", "GIGA Cardiovascular, University of Liège, Belgium (M.A., F.D.).", "Biostatistics and Research Methods Centre (B-STAT), CHU de Liège and University of Liège, Belgium (M.E.).", "Stroke-Link, F-CRIN Research Infrastructure, Paris, France (B.M., M.M., J.-P.D., F.D.).", "Neurology Department (P.S.), Rothschild Foundation Hospital, Paris, France.", "Neuro-Intensive Care Unit, Rothschild Foundation Hospital, Paris, France (N.E.).", "Anesthesiology Department (S.C.), Rothschild Foundation Hospital, Paris, France.", "Université Paris-Cité, U1144 INSERM, Therapeutic optimization in Neuropsychopharmacology, France (B.H.-T.-N., M.M., J.-P.D.).", "Neurology Department, University Hospital of Toulouse, France (J.-M.O.).", "Neuroradiology Department (A.B.-S.), Pierre Wertheimer Hospital, Bron, France.", "Neurology Department, CHU Sart-Tilman, Liège, Belgium (F.D.)." ], "article_type": "research article", "arxiv": null, "author_total": 24, "authors": [ { "affs": [ 0, 1, 2 ], "name": "Andrea Gambino", "orcid": "0000-0002-9142-1331" }, { "affs": [ 3 ], "name": "David Weisenburger-Lile" }, { "affs": [ 0 ], "name": "Aurélien Freiherr von Seckendorff" }, { "affs": [ 4 ], "name": "Manar Abomulay", "orcid": "0009-0002-5578-9304" }, { "affs": [ 5 ], "name": "Marie Ernst", "orcid": "0000-0002-9002-5783" }, { "affs": [ 0, 6 ], "name": "Benjamin Maïer", "orcid": "0000-0003-3993-1024" }, { "affs": [ 7 ], "name": "Pierre Seners", "orcid": "0000-0002-2134-0691" }, { "affs": [ 0 ], "name": "Michel Piotin", "orcid": "0000-0002-1354-4328" }, { "affs": [ 0 ], "name": "Raphaël Blanc", "orcid": "0000-0002-3975-3865" }, { "affs": [ 0 ], "name": "Simon Escalard", "orcid": "0000-0003-1306-1008" }, { "affs": [ 0 ], "name": "William Boisseau" }, { "affs": [ 0 ], "name": "Amira Al Raaisi" }, { "affs": [ 0 ], "name": "Hocine Redjem", "orcid": "0000-0002-6943-9922" }, { "affs": [ 0 ], "name": "Stanislas Smajda" }, { "affs": [ 0 ], "name": "Erwan Robichon" }, { "affs": [ 0 ], "name": "Humain Baharvahdat", "orcid": "0000-0002-1154-8843" }, { "affs": [ 8 ], "name": "Nicolas Engrand", "orcid": "0000-0002-6051-5474" }, { "affs": [ 9 ], "name": "Simon Clariot" }, { "affs": [ 10 ], "name": "Benoit Ho-Tin-Noé", "orcid": "0000-0002-7428-1760" }, { "affs": [ 11 ], "name": "Jean-Marc Olivot", "orcid": "0000-0003-2027-2276" }, { "affs": [ 12, 2 ], "name": "Alexandre Bani-Sadr", "orcid": "0000-0002-1808-2484" }, { "affs": [ 0, 10, 6 ], "name": "Mikael Mazighi", "orcid": "0000-0003-0911-8999" }, { "affs": [ 0, 10, 6 ], "name": "Jean-Philippe Désilles", "orcid": "0000-0001-8395-6312" }, { "affs": [ 0, 4, 13, 6 ], "name": "François Delvoye", "orcid": "0000-0002-0697-2156" } ], "bibtex": "https://research.draconitic.com/paper/djhxa9nx8jjbv.bib", "cited_by": 0, "doi": "10.1161/svin.126.002475", "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727233/?tool=EBI", "id": "djhxa9nx8jjbv", "issns": [ "2694-5746" ], "landing_url": "https://europepmc.org/article/PMC/PMC13727233", "language": "eng", "licence": "CC-BY-NC", "licence_label": "CC BY-NC", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "10015" ], [ "heading", "10030" ], [ "heading", "10043" ], [ "heading", "10053" ], [ "heading", "10066,10178" ], [ "heading", "Original Research" ], [ "openalex", "2713|Acute Ischemic Stroke Management" ] ], "openalex": "W7213464390", "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727233/pdf/?tool=EBI", "pmcid": "PMC13727233", "pmid": "42974594", "published": "2026-09-17", "publisher": "Wolters Kluwer Health", "ris": "https://research.draconitic.com/paper/djhxa9nx8jjbv.ris", "sources": [ { "first_seen": "2026-11-03T15:20:51Z", "native_id": "PMC:PMC13727233", "source": "europepmc", "url": "https://europepmc.org/article/PMC/PMC13727233" }, { "first_seen": "2026-11-04T15:20:49Z", "native_id": "MED:42974594", "source": "europepmc", "url": "https://europepmc.org/article/MED/42974594" }, { "first_seen": "2026-11-05T12:23:21Z", "native_id": "PMC13727233", "source": "pmc", "url": "https://doi.org/10.1161/svin.126.002475" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2713|Acute Ischemic Stroke Management", "subfield": "epidemiology-public-health" } ], "title": "Predictors of Hemorrhagic Transformation After IV Continuous Cangrelor Infusion Initiated During Mechanical Thrombectomy", "title_text": "Predictors of Hemorrhagic Transformation After IV Continuous Cangrelor Infusion Initiated During Mechanical Thrombectomy", "type": "peer-reviewed", "updated_at": "2026-11-06T12:22:57Z", "url": "https://research.draconitic.com/paper/djhxa9nx8jjbv", "venue": "Stroke (Hoboken, N.J.)", "versions": [] }