{
  "abstract": "Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodegeneration, metabolic disorders, and cardiovascular diseases. Therapeutic strategies targeting aging hallmarks can delay aging and mitigate disease risk. Emerging interventions focus on modulating core aging mechanisms, including cellular senescence, metabolic dysfunction, epigenetic alterations, and mitochondrial impairment, etc. Recent advances have focused on three strategies: senolytics (eliminating senescent cells, e.g., dasatinib + quercetin), senomorphics (inhibiting the senescence-associated secretory phenotype, e.g., rapamycin), and senoreversion (rejuvenating senescent cells via epigenetic reprogramming). Additionally, metabolic interventions such as caloric restriction mimetics (e.g., spermidine, α-ketoglutarate, ergothioneine) enhance mitochondrial function, activate autophagy, and reprogram energy metabolism, demonstrating lifespan extension and healthspan improvement in preclinical models. Collectively, these approaches hold promise for delaying aging and alleviating age-related pathologies, facilitating the transition to precision longevity medicine. Concurrently, artificial intelligence (AI) accelerates discovery by integrating multiomics data, predicting candidate compounds, identifying biomarkers, and enabling personalized interventions. Despite advancements, challenges remain in target specificity, off-target effects, and clinical translation. The convergence of AI, multitarget strategies, and precision medicine signals a transformative era in extending healthspan and combating aging-associated diseases. This review systematically summarizes current breakthroughs, clinical landscapes, and future directions in aging therapeutics, underscoring interdisciplinary strategies to redefine healthy aging.",
  "abstract_shown": true,
  "affiliations": [
    "National University of Singapore (Suzhou) Research Institute, Suzhou, China",
    "Healthy Aging Research Center, Nutrilite Health Institute, Shanghai, China",
    "Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore",
    "Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore",
    "Institute of Quality Standards and Testing Technology for Agro-Products of Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Beijing, China. xuzhenzhen@caas.cn",
    "Healthy Aging Research Center, Nutrilite Health Institute, Shanghai, China. Eric.Du@amway.com",
    "Department of Food Science & Technology, National University of Singapore, Singapore, Singapore. dejian@nus.edu.sg",
    "National University of Singapore (Suzhou) Research Institute, Suzhou, China. dejian@nus.edu.sg"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruifang Dong"
    },
    {
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        1
      ],
      "name": "Qiming Wu"
    },
    {
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        1
      ],
      "name": "Juntao Kan",
      "orcid": "0000-0001-7280-6394"
    },
    {
      "affs": [
        0
      ],
      "name": "Caili Fu",
      "orcid": "0000-0001-7707-5914"
    },
    {
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        2,
        3
      ],
      "name": "Vincenzo Sorrentino",
      "orcid": "0000-0002-7212-370X"
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    {
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        2,
        3
      ],
      "name": "Ashley Chow"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanan Lei"
    },
    {
      "affs": [
        0
      ],
      "name": "Di Wu"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhenzhen Xu",
      "orcid": "0000-0003-4111-3530"
    },
    {
      "affs": [
        5
      ],
      "name": "Jun Du"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Dejian Huang",
      "orcid": "0000-0002-2305-3960"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/djxa6vs7djdaz.bib",
  "cited_by": 10,
  "doi": "10.1038/s41392-026-02662-z",
  "fulltext_url": null,
  "id": "djxa6vs7djdaz",
  "issns": [
    "2059-3635",
    "2095-9907"
  ],
  "landing_url": "https://doi.org/10.1038/s41392-026-02662-z",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
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  "pdf_url": "https://www.nature.com/articles/s41392-026-02662-z.pdf",
  "pmcid": "PMC13226726",
  "pmid": "42225652",
  "published": "2026-06-01",
  "publisher": "Springer Nature",
  "ris": "https://research.draconitic.com/paper/djxa6vs7djdaz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:48Z",
      "native_id": "W7162995047",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41392-026-02662-z"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Insights into the therapeutic strategies for aging and aging-associated diseases",
  "title_text": "Insights into the therapeutic strategies for aging and aging-associated diseases",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:20:49Z",
  "url": "https://research.draconitic.com/paper/djxa6vs7djdaz",
  "venue": "Signal Transduction and Targeted Therapy",
  "versions": []
}