{
  "abstract": "Human reproduction and development span a continuum shaped by genetic, molecular, and environmental factors. However, relevant data remain dispersed across public repositories and the literature, limiting systematic integration, analysis, and reuse. We developed the Human Reproduction and Development Database (HRD; http://www.inbirg.com/hrd/), an integrated multi-omics resource that organizes publicly available data relevant to multiple reproductive, pregnancy, and developmental contexts. HRD version 1.0 contains 814 omics records, including 432 bulk transcriptomic, 144 single-cell or single-nucleus transcriptomic, 156 epigenomic, 52 metabolomic, and 30 proteomic records, together with 702 clinical trial records, 293 exposure-outcome associations, and 779 lead SNPs with curated phenotype associations. By harmonising key metadata and applying data-type-specific analysis workflows, HRD brings omics data, genetic associations, exposure-outcome evidence, and clinical trial data into a common framework for exploring data from multiple stages of reproduction and development. The website supports keyword search, combined filtering, category-based browsing, statistical summaries and data downloads, and provides interactive visualizations of differential analyses, functional enrichment, cell clustering, chromatin accessibility, peak annotation, regulatory networks, and cross-phenotype association plots. HRD supports the retrieval, comparison, and reuse of reproductive and developmental data and analysis results.",
  "abstract_shown": true,
  "affiliations": [
    "Reproductive Medicine Center, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,",
    "Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University , Chongqing 400016 ,",
    "Joint International Research Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University , Chongqing 400016 ,",
    "School of Pharmaceutical Sciences, Southwest University , Chongqing 400715 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chang Liu"
    },
    {
      "affs": [
        1
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      "name": "Xu Zhang"
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    {
      "affs": [
        0,
        2
      ],
      "name": "Tingyuan Lang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lifei Feng"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Liu"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Tianyu Yang"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Meirong Xiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunfan Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinrui Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Tinghui Xie"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xiru Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianbo Pan",
      "orcid": "0000-0001-6014-8160"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/djyx5694j1dy1.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1006",
  "fulltext_url": null,
  "id": "djyx5694j1dy1",
  "issns": [
    "0305-1048",
    "1362-4962"
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  "language": null,
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
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  "native_subjects": [
    [
      "openalex",
      "1312|Bioinformatics and Genomic Networks"
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  "openalex": "W7222979251",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1006/72085431/gkag1006.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/djyx5694j1dy1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1006",
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      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1006/8937187"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bioinformatics and Genomic Networks",
      "subfield": "molecular-biology"
    }
  ],
  "title": "HRD: an integrated multi-omics resource for human reproduction and development",
  "title_text": "HRD: an integrated multi-omics resource for human reproduction and development",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/djyx5694j1dy1",
  "venue": "Nucleic Acids Research",
  "versions": []
}