{
  "abstract": "An attempt to improve a microwave-promoted iminyl radical cyclization cascade targeting the Securinega alkaloid virosinine A revealed that the process could be initiated at lower temperatures (66 °C versus 100 °C) under Finkelstein conditions. Mechanistic experiments and DFT calculations indicate that Finkelstein bromination or iodination facilitates intramolecular N-alkylation. This lowers the N–O BDE of the substrate and permits homolysis at lower temperatures than previously observed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry and Biochemistry",
    "Brigham Young University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
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        1
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      "name": "Osasere J. Osayawe"
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    {
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        1
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      "name": "Joshua D. Morgan"
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    {
      "affs": [
        0,
        1
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      "name": "Benjamin T. Melton"
    },
    {
      "affs": [
        0,
        1
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      "name": "Ethan P. Downing"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jesus A. Botello"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexander Ramos"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Steven L. Castle"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dk1x1wnza0paa.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009361/v1",
  "fulltext_url": null,
  "id": "dk1x1wnza0paa",
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  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009361/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
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  "openalex": "W7214123405",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009361/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/dk1x1wnza0paa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009361",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009361/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Intramolecular N-Alkylation of O-Aryloximes Facilitates N–O Homolysis and Iminyl Radical Cyclization",
  "title_text": "Intramolecular N-Alkylation of O-Aryloximes Facilitates N–O Homolysis and Iminyl Radical Cyclization",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/dk1x1wnza0paa",
  "venue": "ChemRxiv",
  "versions": []
}