{
  "abstract": "Background: Chronic lymphocytic leukemia (CLL) is associated with increased fracture risk unexplained by standard bone density scans, suggesting underlying microstructural alterations. Whether leukemic infiltration disrupts the bone marrow microenvironment at the structural level remains poorly understood.\n\nMethods: We used high-resolution synchrotron micro-computed tomography (SR μ CT) on bone marrow biopsies from 17 CLL patients, stratified into low and high infiltration groups using objective, data-driven k-means clustering. Osteocyte lacunar density and intertrabecular marrow surface area-to-volume ratio (SA:V) were quantified using image processing and deep learning segmentation. Sensitivity analyses adjusting for prior therapy were performed using linear regression.\n\nResults: Here we show that high CLL marrow infiltration is associated with a 40.3% reduction in lacunar density and a 101% increase in normalized intertrabecular marrow SA:V, a metric reflecting greater structural fragmentation of the marrow compartment. Both changes correlate with leukemic infiltration percentage and show partial reversal after therapy in a longitudinal case.\n\nConclusions: We identify a marrow remodeling phenotype in CLL characterized by osteocyte depletion and intertrabecular marrow disruption. These changes likely contribute to skeletal fragility and represent potential microstructural biomarkers for assessing marrow health more accurately than conventional imaging.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "In Kyu Lee",
      "orcid": "0000-0001-5554-808X"
    },
    {
      "name": "Yoshihiro Obata"
    },
    {
      "name": "Anthony D. Pomicter",
      "orcid": "0000-0002-3977-0841"
    },
    {
      "name": "Justin A. Williams",
      "orcid": "0000-0001-9510-3165"
    },
    {
      "name": "Bejal Kikani"
    },
    {
      "name": "Christopher E. Jensen"
    },
    {
      "name": "Douglas W. Sborov",
      "orcid": "0000-0003-4268-2698"
    },
    {
      "name": "Deborah M. Stephens"
    },
    {
      "name": "Claire Acevedo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dk4ct7f66226k.bib",
  "cited_by": 0,
  "doi": "10.1038/s43856-026-01945-4",
  "fulltext_url": null,
  "id": "dk4ct7f66226k",
  "issns": [
    "2730-664X"
  ],
  "landing_url": "https://www.nature.com/articles/s43856-026-01945-4",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7223142123",
  "pdf_url": "https://www.nature.com/articles/s43856-026-01945-4_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/dk4ct7f66226k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "10.1038/s43856-026-01945-4",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s43856-026-01945-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Disruption of marrow microenvironments in chronic lymphocytic leukemia by high-resolution synchrotron micro-computed tomography",
  "title_text": "Disruption of marrow microenvironments in chronic lymphocytic leukemia by high-resolution synchrotron micro-computed tomography",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/dk4ct7f66226k",
  "venue": "Communications Medicine",
  "versions": []
}