{
  "abstract": "The first chemical synthesis of phosphoisocitrate [1-(phosphonooxy)propane-1,2,3-tricarboxylic acid, i-PC], a structural isomer of phosphocitrate (PC, natural regulator found in mammalian cells) is reported.Isocitrate is an essential metabolite within the cellular citric acid cycle.Although i-PC may form in vivo via the phosphorylation of isocitrate, it has remained uncharacterized in literature.Phosphocitrate [2-(phosphonooxy)propane-1,2,3-tricarboxylic acid, PC] synthesis was previously reported on a ~200 mg scale.Here an improved synthetic procedure for PC on a multi-gram scale is presented.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Petri Turhanen",
      "orcid": "0000-0002-7546-8906"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dkhk8h5hfeb0b.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009122/v1",
  "fulltext_url": null,
  "id": "dkhk8h5hfeb0b",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009122/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organophosphorus compounds synthesis"
    ]
  ],
  "openalex": "W7213933724",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009122/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/dkhk8h5hfeb0b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15009122",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009122/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organophosphorus compounds synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Chemical Synthesis of the endogenous metabolite Phosphocitrate and Its Structural Isomer Phosphoisocitrate",
  "title_text": "Chemical Synthesis of the endogenous metabolite Phosphocitrate and Its Structural Isomer Phosphoisocitrate",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/dkhk8h5hfeb0b",
  "venue": "ChemRxiv",
  "versions": []
}