{
  "abstract": "Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT 1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown. Using co-immunoprecipitation, BRET, confocal, and super-resolution microscopy in hippocampal and 5-HT neurons, we present evidence that 5-HT 1A and 5-HT 2B receptors can form heterodimers and co-cluster at the plasma membrane of dendrites. Selective agonist stimulation of coexpressed 5-HT 1A and 5-HT 2B receptors prevents 5-HT 1A receptor internalization and increases 5-HT 2B receptor membrane clustering. Current clamp recordings of 5-HT neurons revealed that 5-HT 1A receptor stimulation of acute slices from mice lacking 5-HT 2B receptors in 5-HT neurons increased their firing activity trough Ca 2+ -activated potassium channel inhibition compared to 5-HT neurons from control mice. This work supports the hypothesis that the relative expression of 5-HT 1A and 5-HT 2B receptors tunes the neuronal excitability of serotonergic neurons through potassium channel regulation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Amina Benhadda"
    },
    {
      "name": "Célia Delhaye"
    },
    {
      "name": "Imane Moutkine"
    },
    {
      "name": "Xavier Marques"
    },
    {
      "name": "Marion Russeau"
    },
    {
      "name": "Corentin Le Magueresse"
    },
    {
      "name": "Anne Roumier"
    },
    {
      "name": "Sabine Lévi"
    },
    {
      "name": "Luc Maroteaux"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dkscfnpzwz4pc.bib",
  "cited_by": 7,
  "doi": "10.1016/j.isci.2023.107401",
  "fulltext_url": null,
  "id": "dkscfnpzwz4pc",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://hal.science/hal-05783999v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
  ],
  "openalex": "W4384408285",
  "pdf_url": "http://www.cell.com/article/S2589004223014785/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "Cell Press, Elsevier [2018-....]",
  "ris": "https://research.draconitic.com/paper/dkscfnpzwz4pc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "hal-05783999",
      "source": "hal",
      "url": "https://hal.science/hal-05783999v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    }
  ],
  "title": "5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability",
  "title_text": "5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:50Z",
  "url": "https://research.draconitic.com/paper/dkscfnpzwz4pc",
  "venue": "iScience",
  "versions": []
}