{
  "abstract": "Isotopic chirality arising from hydrogen/deuterium substitution has long resisted optical resolution because isotopic substitution introduces only minimal stereochemical differences, rendering such molecules structurally pseudo-achiral. Recognizing that the small yet distinct difference in C–H/C–D bond dissociation energies (BDEs) creates an energetic asymmetry, we envisioned that an enantioselective C–H functionalization exploiting this disparity could achieve the kinetic resolution of isotopically chiral molecules. Here, we report a catalytic method for the optical resolution of benzylic and allylic H/D isotopic chirality. This method achieved a remarkably high separation factor ( S = 83.1), enabling the isolation of highly enantioenriched isotopically chiral substrates from racemic mixtures and revealing retention of stereochemical memory during radical recombination in asymmetric C–H functionalization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Graduate School of Sciences, Kyushu University; Fukuoka, 819-0395, Japan.",
    "International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University; Fukuoka, 819-0395, Japan.",
    "Faculty of Arts and Science, Kyushu University; Fukuoka, 819-0395, Japan.",
    "JST PRESTO; Tokyo, 102-0076, Japan.",
    "Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka 816-8580, Japan."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Tatsuya Uchida",
      "orcid": "0000-0002-6511-5752"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuta Nakagawa",
      "orcid": "0009-0009-3858-7007"
    },
    {
      "affs": [
        0
      ],
      "name": "Naoki Watari"
    },
    {
      "affs": [
        4
      ],
      "name": "Yuuya Kawasaki",
      "orcid": "0000-0003-3354-1690"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dm40dhy0ydbm2.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aed4187",
  "fulltext_url": null,
  "id": "dm40dhy0ydbm2",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aed4187",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7220849314",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/dm40dhy0ydbm2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aed4187",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aed4187"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Optical resolution of H/D isotopic chirality via asymmetric C–H amination",
  "title_text": "Optical resolution of H/D isotopic chirality via asymmetric C–H amination",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/dm40dhy0ydbm2",
  "venue": "Science Advances",
  "versions": []
}