{
  "abstract": "Sacha inchi ( Plukenetia volubilis L.) oil is among the richest plant-derived sources of alpha-linolenic acid (ALA), offering vegetarians a plant-based route to omega-3 fatty acid. This study encompasses around the characterization of cold-pressed Sacha inchi oil (SIO) combining physicochemical quality assessment and molecular composition. GC-FID analysis quantified five major fatty acids, with ALA as the predominant fatty acid (49.61 ± 0.05%), with total PUFA content of 84.25 ± 0.07%, with a ω-6:ω-3 ratio of 0.70:1. LC–MS/MS analysis revealed a total tocopherol content of 492.685 ± 0.049 mg kg⁻¹. SIO exhibited concentration-dependent DPPH (IC₅₀ = 24.94 ± 2.58 µg mL⁻¹) and ABTS radical scavenging activity (IC₅₀ = 31.99 ± 1.13 µg mL⁻¹). In RAW 264.7 macrophages, SIO showed concentration-dependent effects on cell viability, with IC₅₀ values of 213.40 ± 5.73 µg/mL in LPS untreated cells. SIO also reduced LPS-induced NO production by 6.05–49.62% at 10–75 µg mL⁻¹. And exhibits cytotoxicity against MDA-MB-231 triple-negative breast cancer cells (IC₅₀ = 15.08 µg mL⁻¹; 95% CI: 14.14–16.06 µg mL⁻¹) and HEK-293 cells (IC₅₀ = 45.53 µg mL⁻¹; 95% CI: 43.02–48.02 µg mL⁻¹). These findings highlight the compositional richness of SIO and support its potential as PUFA-rich functional food ingredient.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Gobika Shanmugam",
      "orcid": "0009-0009-4464-7379"
    },
    {
      "name": "Renganathan Sahadevan",
      "orcid": "0000-0003-3317-1677"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dm99ct5hx0k3z.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-75571-4",
  "fulltext_url": null,
  "id": "dm99ct5hx0k3z",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-75571-4",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Edible Oils Quality and Analysis"
    ]
  ],
  "openalex": "W7221467592",
  "pdf_url": "https://www.nature.com/articles/s41598-026-75571-4_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-11",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/dm99ct5hx0k3z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.1038/s41598-026-75571-4",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-75571-4"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Edible Oils Quality and Analysis",
      "subfield": "organic"
    }
  ],
  "title": "Physicochemical quality, molecular composition, tocopherol profiling, and in vitro activity of cold-pressed Sacha inchi (Plukenetia volubilis L.) oil",
  "title_text": "Physicochemical quality, molecular composition, tocopherol profiling, and in vitro activity of cold-pressed Sacha inchi (Plukenetia volubilis L.) oil",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/dm99ct5hx0k3z",
  "venue": "Scientific Reports",
  "versions": []
}