{
  "abstract": "We present cryogenic ion vibrational spectroscopy of deprotonated L-proline ([Pro-H]-) complexed with octamethyl calix[4]pyrrole (omC4P). Density functional theory calculations reveal two low-energy binding motifs. In the lowest energy structure, the carboxylate group interacts with only three NH groups of omC4P, with the NH group of the fourth pyrrole pointing away from the binding site. In another geometry, slightly higher in energy, the ion binds to all four NH groups. The experimental IR spectrum matches the lowest energy isomer, featuring a free NH stretching signature at 3439 cm-1 alongside strongly red-shifted NH stretching modes involving the three strong hydrogen-bonding NH groups. This three-point binding motif represents a departure from the typical four-point binding observed with smaller anions, demonstrating how the charge distribution of the guest and the structural flexibility of the receptor affect binding of larger anions. Despite the reduced number of hydrogen bonds, the three-point binding motif is lower in energy due to shorter, stronger hydrogen bonds, and it is the dominant motif of [Pro-H]-·omC4P in vacuo.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Lane M. Terry"
    },
    {
      "name": "J. Mathias Weber",
      "orcid": "0000-0002-5493-5886"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dmhd8epzy6py4.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009132/v1",
  "fulltext_url": null,
  "id": "dmhd8epzy6py4",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009132/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Supramolecular Chemistry and Complexes"
    ]
  ],
  "openalex": "W7213940892",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009132/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/dmhd8epzy6py4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15009132",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009132/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Supramolecular Chemistry and Complexes",
      "subfield": "organic"
    }
  ],
  "title": "Influence of Structural Flexibility on Ion-Receptor Interactions in Octamethyl Calix[4]pyrrole Complexed with Prolinate",
  "title_text": "Influence of Structural Flexibility on Ion-Receptor Interactions in Octamethyl Calix[4]pyrrole Complexed with Prolinate",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/dmhd8epzy6py4",
  "venue": "ChemRxiv",
  "versions": []
}