{
  "abstract": "Studying how drugs act on neuronal circuits requires delivering them with temporal precision while behavior proceeds undisturbed, a combination that tethered infusion systems cannot provide. We developed WEARIT (Wireless Equipment for Autonomous Rat Infusion Tasks), a wearable, tetherless infusion platform that gives freely moving rats intravenous access under either remote or closed-loop operant control. The device houses a reservoir, miniaturized pump, rechargeable battery and Bluetooth circuitry in a 3D-printed enclosure worn on the back. By measuring spontaneous locomotion, amphetamine-induced hyperlocomotion and food-reinforced operant responding, we show that WEARIT leaves these behaviors unchanged. Remotely triggered fentanyl infusions yielded reliable delivery with physiological responses confirmed by pulse oximetry, and self-administration acquisition and dose-response functions were comparable to conventional tethered systems. WEARIT removes a longstanding constraint on intravenous pharmacology, opening self-administration paradigms to naturalistic and enriched environments and to concurrent imaging or optogenetic manipulation of the circuits engaged by drug reinforcement.",
  "abstract_shown": true,
  "affiliations": [
    "Washington University in St. Louis"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "E. Y. Jeong"
    },
    {
      "name": "C. D. Teague"
    },
    {
      "name": "A. Reimert"
    },
    {
      "name": "S. Cho"
    },
    {
      "name": "J. Lee"
    },
    {
      "name": "T. Althoff"
    },
    {
      "name": "K. Lin"
    },
    {
      "name": "M. Nair"
    },
    {
      "name": "T. Leong"
    },
    {
      "name": "E. Silva"
    },
    {
      "name": "K. E. Parker"
    },
    {
      "name": "C. M. Cahill"
    },
    {
      "affs": [
        0
      ],
      "name": "J. G. McCall"
    },
    {
      "name": "J.-W. Jeong"
    },
    {
      "name": "N. Massaly"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dmxcjhjy4pap2.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.08.750146",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750146v1.full",
  "id": "dmxcjhjy4pap2",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750146v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2204|Intravenous Infusion Technology and Safety"
    ]
  ],
  "openalex": "W7212663506",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750146v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dmxcjhjy4pap2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:21Z",
      "native_id": "10.64898/2026.09.08.750146",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750146v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "A Wireless Wearable Platform for Intravenous Drug Self-Administration in Freely Behaving Rats",
  "title_text": "A Wireless Wearable Platform for Intravenous Drug Self-Administration in Freely Behaving Rats",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:21Z",
  "url": "https://research.draconitic.com/paper/dmxcjhjy4pap2",
  "venue": "bioRxiv",
  "versions": []
}