{
  "abstract": "Objective\n\nTo assess the appropriateness of strong opioid prescribing for chronic non-cancer pain (CNCP) in primary care and to analyse factors associated with inappropriate prescribing.Design\n\nCross-sectional observational study. SITE: Three primary care centres in a health area in northern Spain.Participants\n\nActive prescriptions of strong opioids in adult patients with CNCP. A total of 441 prescriptions corresponding to 387 patients were analysed.Interventions\n\nNo interventions were performed. A retrospective review of prescriptions and electronic health records was conducted.Main measurements\n\nTherapeutic appropriateness according to eight clinical recommendations on indication, previous analgesic escalation, concomitant treatment and safety. Descriptive analysis and multivariable logistic regression were performed.Results\n\nMean age was 67.1years (SD: 16.0), and 71.4% of prescriptions corresponded to women. Overall, 82.8% of prescriptions were considered inappropriate. The most frequent non-adherence criterion was concomitant benzodiazepine use (55.1%). In the multivariable model, age (OR: 1.02; 95%CI: 1.00-1.04; P=.038) and concomitant antidepressant treatment (OR: 4.76; 95%CI: 2.17-10.64; P<.001) were associated with inappropriate prescribing. A high-risk clinical profile was observed in 31.5% of prescriptions.Conclusions\n\nStrong opioid prescribing for CNCP showed a high proportion of inappropriate use. These findings support the implementation of prescribing review and medication safety interventions in primary care.",
  "abstract_shown": true,
  "affiliations": [
    "Centro de Salud Las Vegas, Área Sanitaria III, Servicio de Salud del Principado de Asturias, Corvera de Asturias, Asturias, España.",
    "Centro de Salud de Pravia, Área Sanitaria III, Servicio de Salud del Principado de Asturias, Pravia, Asturias, España.",
    "Centro de Salud Sabugo, Área Sanitaria III, Servicio de Salud del Principado de Asturias, Avilés, Asturias, España.",
    "Gerencia de Mieres Sur, Área Sanitaria VII, Servicio de Salud del Principado de Asturias, Mieres, Asturias, España. Electronic address: luis.solis@sespa.es.",
    "Universitätsspital Zürich (USZ), University of Zurich, Zúrich, Suiza."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jorge Díaz-Piñeiro"
    },
    {
      "affs": [
        1
      ],
      "name": "José Ignacio González-González"
    },
    {
      "affs": [
        2
      ],
      "name": "Eric Bismar Infante-Peralta"
    },
    {
      "affs": [
        0
      ],
      "name": "Miguel Solís-González"
    },
    {
      "affs": [
        3
      ],
      "name": "Luis Solís-González"
    },
    {
      "affs": [
        4
      ],
      "name": "Guillermo Palomar-Ramos"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dn771c5t59bre.bib",
  "cited_by": 0,
  "doi": "10.1016/j.aprim.2026.103601",
  "fulltext_url": "https://europepmc.org/articles/PMC13693082",
  "id": "dn771c5t59bre",
  "issns": [
    "0212-6567",
    "1578-1275"
  ],
  "landing_url": "https://europepmc.org/article/MED/42874373",
  "language": "spa",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Opioid Use Disorder Treatment"
    ]
  ],
  "openalex": "W7221755347",
  "pdf_url": "https://europepmc.org/articles/PMC13693082?pdf=render",
  "pmcid": "PMC13693082",
  "pmid": "42874373",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dn771c5t59bre.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42874373",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42874373"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Opioid Use Disorder Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "[Appropriateness of strong opioid prescribing chronic non-cancer pain in primary care: a cross-sectional study].",
  "title_text": "[Appropriateness of strong opioid prescribing chronic non-cancer pain in primary care: a cross-sectional study].",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/dn771c5t59bre",
  "venue": "Atencion primaria",
  "versions": []
}