{
  "abstract": "Uterine aging impairs fertility and reproductive health, but the underlying pathogenic mechanisms and effective treatment strategies remain elusive. Defective endometrial decidualization and implantation failure are hallmarks of uterine aging, which can be driven by cellular senescence, especially in endometrial stromal cells (EnSCs). Rb1 has been reported to relieve cellular senescence by suppressing oxidative and inflammatory pathways. However, whether Rb1 functions in alleviating uterine aging remains uncertain. Here, we demonstrate that Rb1 can attenuate oxidative stress, senescence, and apoptosis in the EnSCs of the aging human endometrium and murine uterus. Further proteomic analysis reveals that Rb1 safeguards against endometrial aging by regulating mammalian target of rapamycin (mTOR)-related pathways. Rb1 treatment results in the activation of AMP-activated protein kinase (AMPK) and AMPK-mediated suppression of the mTOR-nuclear factor-kappa B (NF-κB) signaling loop, thereby ameliorating aging-related phenotypes. Collectively, our findings illustrate that Rb1 alleviates uterine aging by attenuating endometrial stromal cell senescence and suppressing AMPK–mTOR–NF-κB-driven inflammatory signaling. Rather than selectively eliminating senescent cells, Rb1 primarily targets senescence-associated dysfunction and restores endometrial homeostasis, highlighting its potential as a senescence-modulating therapeutic strategy for uterine aging.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China",
    "Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China",
    "Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China",
    "National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China",
    "National Clinical Key Specialty Construction Program, P.R. China (2023), Beijing, China",
    "Department of Medicine, Boston University School of Medicine, Boston, MA USA",
    "Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China",
    "Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ping Zhou"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yue Wang",
      "orcid": "0000-0002-0737-6479"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ming Cheng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Feng Deng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Fenting Liu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Xiunan Chen"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ke Ning"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Dan Mo"
    },
    {
      "affs": [
        0,
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        2,
        3,
        4
      ],
      "name": "Zhonghong Zeng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ziying Huang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yunshu Dong"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yinxue Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Chao Zhang",
      "orcid": "0000-0001-8019-7998"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Jie Qiao",
      "orcid": "0000-0003-2126-1376"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        6,
        7
      ],
      "name": "Yang Yu",
      "orcid": "0000-0002-4310-1966"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Heng Pan",
      "orcid": "0000-0002-5407-5687"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Rong Li",
      "orcid": "0000-0003-0305-5579"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dnqdmcry9vy6x.bib",
  "cited_by": 0,
  "doi": "10.1038/s41392-026-02970-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714316/",
  "id": "dnqdmcry9vy6x",
  "issns": [
    "2095-9907",
    "2059-3635"
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  "landing_url": "https://doi.org/10.1038/s41392-026-02970-4",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "1312|Ginseng Biological Effects and Applications"
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  "pdf_url": "https://www.nature.com/articles/s41392-026-02970-4.pdf",
  "pmcid": "PMC13714316",
  "pmid": "42946698",
  "published": "2026-10-28",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/dnqdmcry9vy6x.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:50Z",
      "native_id": "PMC13714316",
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      "url": "https://doi.org/10.1038/s41392-026-02970-4"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Ginseng Biological Effects and Applications",
      "subfield": "molecular-biology"
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  ],
  "title": "Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation",
  "title_text": "Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:50Z",
  "url": "https://research.draconitic.com/paper/dnqdmcry9vy6x",
  "venue": "Signal Transduction and Targeted Therapy",
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