{
  "abstract": "Background: Disease recurrence is common after surgery for pleural mesothelioma (PM), and the evidence guiding post-recurrence management remains limited. Methods: We conducted a retrospective, single-center cohort study including patients with PM treated within a curative-intent multimodality treatment pathway including surgery aiming for a macroscopic complete resection when feasible between 2001 and 2024. Post-recurrence treatments were categorized as best supportive care only (BSC), systemic therapy alone, or local with or without systemic therapy. Survival and disease-free outcomes were analyzed in relation to treatment patterns and clinical prognostic factors. Results: Among 67 patients with a median follow-up time of 107 months from surgery, 58 (86.6%) developed disease recurrence. At first recurrence, 21 patients (36%) received local with or without systemic therapy, 26 (45%) systemic therapy alone, and 11 (19%) BSC. The median post-recurrence survival was 21.7 months for patients receiving local with or without systemic therapy, 10.8 months for systemic therapy alone, and 1.6 months for BSC. Lung-sparing surgery and a disease-free interval of at least 12 months were associated with improved post-recurrence survival and post-recurrence progression-free survival. Conclusions: In this real-world cohort of patients with PM and extended follow-up, active post-recurrence treatment was associated with longer post-recurrence survival in selected patients. However, conclusions regarding their comparative effectiveness are limited by the retrospective design, incomplete recurrence-related data, and patient selection at recurrence.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria",
    "Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, 1210 Vienna, Austria",
    "Department of Respiratory and Pulmonary Diseases, Klinik Hietzing, Vienna Healthcare Group, 1130 Vienna, Austria",
    "Department of Thoracic Surgery, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria",
    "Karl Landsteiner Institute for Thoracic Surgical Research, Klinik Floridsdorf, 1210 Vienna, Austria",
    "Paracelsus Medical University, 5020 Salzburg, Austria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Oliver Illini",
      "orcid": "0000-0002-7322-7092"
    },
    {
      "affs": [
        1
      ],
      "name": "Hannah Fabikan"
    },
    {
      "affs": [
        2
      ],
      "name": "Irene Berghammer"
    },
    {
      "affs": [
        1
      ],
      "name": "Julie Krainer-Jacobs",
      "orcid": "0000-0002-2953-7982"
    },
    {
      "affs": [
        3
      ],
      "name": "Amelie Schneeweiss-Worel"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Leyla Ay"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Daniel Moser"
    },
    {
      "affs": [
        1
      ],
      "name": "Christoph Weinlinger"
    },
    {
      "affs": [
        1
      ],
      "name": "Anna Lang-Stöberl"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maximilian J. Hochmair",
      "orcid": "0000-0002-8673-2450"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Michal Benej"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Tibor Krajc"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Thomas Klikovits"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Arschang Valipour"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Stefan Watzka",
      "orcid": "0000-0002-4149-4890"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dphcg3ngf2g24.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208137",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706363/?tool=EBI",
  "id": "dphcg3ngf2g24",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8137",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Occupational and environmental lung diseases"
    ]
  ],
  "openalex": "W7212262772",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706363/pdf/?tool=EBI",
  "pmcid": "PMC13706363",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/dphcg3ngf2g24.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15208137",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8137"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13706363",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706363"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Occupational and environmental lung diseases",
      "subfield": "general"
    }
  ],
  "title": "Post-Recurrence Treatment Patterns and Outcomes After Curative-Intent Multimodality Strategy in Patients with Pleural Mesothelioma: A Retrospective Cohort Study",
  "title_text": "Post-Recurrence Treatment Patterns and Outcomes After Curative-Intent Multimodality Strategy in Patients with Pleural Mesothelioma: A Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/dphcg3ngf2g24",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}