{
  "abstract": "Background/Objectives: Aflatoxin B1 (AFB1) contamination of maize and peanut is influenced by fungal responses to environmental and food-matrix cues, but the transcriptional coordination of redox adaptation, lipid metabolism, and aflatoxin biosynthesis remains unresolved. This study examined whether an expression-defined redox–lipid state is associated with high relative aflatoxin biosynthetic activity in Aspergillus flavus. Methods: A cross-dataset secondary analysis integrated 18 analytical datasets (247 samples) derived from eight public source records spanning defined-medium, maize, and peanut systems. Harmonized expression profiles were used to derive an aflatoxin biosynthetic activity score (ABAS), oxidative-stress adaptation score (OSAS), and lipid metabolic reprogramming score (LMRS). ABAS is an expression-derived relative score, not a direct measure of biosynthetic flux or accumulated toxin. Dataset-aware mixed-effects models evaluated the OSAS–ABAS association and the linear OSAS × LMRS interaction. Results: ABAS correlated with matched AFB1 measurements in 54 samples (Pearson r=0.734, p=2.70×10−10). The quadratic OSAS term was negative (β=−0.434, 95% CI −0.502 to −0.366; p<0.001), with maximum predicted ABAS near 0.81 SD on the pooled within-dataset-standardized OSAS scale. Separately, the linear OSAS × LMRS interaction was positive (β=0.284, 95% CI 0.198–0.370; p<0.001), and the high-OSAS/high-LMRS quadrant had the greatest adjusted mean ABAS (0.789, 95% CI 0.661–0.917). Candidate prioritization recovered established regulators and nominated redox- and lipid-associated nodes. Conclusions: The findings identify an associative transcriptional signature across heterogeneous food-relevant conditions and provide focused hypotheses for prospective validation using direct toxin, redox, lipid, flux, and functional measurements.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy",
    "School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China",
    "Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China",
    "Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Tomtebodavägen 18A, Floor 10, SE-171 65 Solna, Sweden"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yirui Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongxin Gui"
    },
    {
      "affs": [
        2
      ],
      "name": "Kai Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Ruochen Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhijian Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Mengyang Wang",
      "orcid": "0009-0005-7812-7786"
    },
    {
      "affs": [
        3,
        1
      ],
      "name": "Rongrong Yang",
      "orcid": "0009-0008-6125-1491"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dpxysws2fg56p.bib",
  "cited_by": 5,
  "doi": "10.3390/metabo16090652",
  "fulltext_url": null,
  "id": "dpxysws2fg56p",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://doi.org/10.3390/metabo16090652",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Mycotoxins in Agriculture and Food"
    ]
  ],
  "openalex": "W7211905649",
  "pdf_url": null,
  "pmcid": "PMC13609595",
  "pmid": "42783777",
  "published": "2026-09-05",
  "publisher": "Multidisciplinary Digital Publishing Institute",
  "ris": "https://research.draconitic.com/paper/dpxysws2fg56p.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T13:20:46Z",
      "native_id": "W7211905649",
      "source": "openalex",
      "url": "https://doi.org/10.3390/metabo16090652"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Mycotoxins in Agriculture and Food",
      "subfield": "plant-biology"
    }
  ],
  "title": "A Redox–Lipid Transcriptional State Is Associated with High Aflatoxin Biosynthetic Activity in Aspergillus flavus",
  "title_text": "A Redox–Lipid Transcriptional State Is Associated with High Aflatoxin Biosynthetic Activity in Aspergillus flavus",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T13:20:32Z",
  "url": "https://research.draconitic.com/paper/dpxysws2fg56p",
  "venue": "Metabolites",
  "versions": []
}