{
  "abstract": "Preventing breast cancer recurrence is a public health challenge. Insulin resistance is a prognostic factor in women who have survived breast cancer. Although the Mediterranean diet (MedDiet) has been associated with a lower risk of insulin resistance, few studies have been conducted in women with breast cancer. The primary objective of this study was to evaluate the effect of a MedDiet-based intervention compared to a low-fat diet (LFD) on HOMA-IR and HOMA-B values after 2 years of follow-up in women beginning treatment after a breast cancer diagnosis. This study is part of the LifeBreast trial, in which 366 women with breast cancer and a mean age of 54 years (SD 9 years) were included. Participants were randomized in a 1:1 ratio to the intervention group receiving MedDiet and the control group receiving LFD. Nutritional education in both groups lasted 2 years. After exclusions, 314 women were included in this analysis. The dependent variables were HOMA-IR (primary outcome) and HOMA-B. For each of these variables, mixed linear models were used to assess changes between groups over time. We found a significant change in HOMA-IR over the 2-year follow-up between both intervention groups. Specifically, we observed a reduction in HOMA-IR of -0.11 (95% CI -0.35, 0.12) in participants in the MedDiet group and an increase of + 0.22 (95% CI -0.02, 0.46) in the LFD group (p group xtime=0.046). Regarding HOMA-B, the change was +28.7 (95% CI 7.3, 44.2) in participants in the MedDiet group and +35.1 (95% CI 19.3, 50.9) in participants in the LFD group (p groupxtime=0.384). In conclusion, a MedDiet intervention achieved a greater reduction in HOMA-IR compared to the LFD intervention. Further research in clinical settings is warranted.\n\nKey messages: • We evaluated a Mediterranean diet intervention vs a low-fat diet intervention among women with breast cancer on HOMA-IR and HOMA-B over 2 years.\n\n• A Mediterranen diet intervention achieved a greater reduction in HOMA-IR compared to the low-fat intervention.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "abstract",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "J Molins"
    },
    {
      "name": "M Olmedo-López Frías"
    },
    {
      "name": "C González-Palacios Torres"
    },
    {
      "name": "I Gómez-Acebo"
    },
    {
      "name": "C Razquin"
    },
    {
      "name": "R Barrios-Rodríguez"
    },
    {
      "name": "T Dierssen-Sotos"
    },
    {
      "name": "E Toledo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dq56jmvm1qnv2.bib",
  "cited_by": 0,
  "doi": "10.1093/eurpub/ckag169.022",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697485/",
  "id": "dq56jmvm1qnv2",
  "issns": [
    "1101-1262",
    "1464-360X"
  ],
  "landing_url": "https://doi.org/10.1093/eurpub/ckag169.022",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "3. PARALLEL PROGRAMME"
    ],
    [
      "heading",
      "AcademicSubjects/MED00860"
    ],
    [
      "heading",
      "AcademicSubjects/SOC01210"
    ],
    [
      "heading",
      "AcademicSubjects/SOC02610"
    ],
    [
      "openalex",
      "2739|Nutritional Studies and Diet"
    ]
  ],
  "openalex": "W7223650253",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13697485/pdf/?tool=EBI",
  "pmcid": "PMC13697485",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/dq56jmvm1qnv2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:32Z",
      "native_id": "PMC13697485",
      "source": "pmc",
      "url": "https://doi.org/10.1093/eurpub/ckag169.022"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13697485",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13697485"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Nutritional Studies and Diet",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The effect of different nutritional interventions on insulin resistance in women with breast cancer",
  "title_text": "The effect of different nutritional interventions on insulin resistance in women with breast cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:31Z",
  "url": "https://research.draconitic.com/paper/dq56jmvm1qnv2",
  "venue": "The European Journal of Public Health",
  "versions": []
}