{
  "abstract": "The HECTD2:rs12249854 polymorphism may be associated with a weaker response to an intradetrusor injection of botulinum neurotoxin type A (BoNT/A) in patients with overactive bladder (OAB). This prospective study analyzed the link between the HECTD2:rs12249854 polymorphism and the response to BoNT/A treatment in 156 OAB patients, based on changes in urodynamic parameters and ICIQ-OAB and ICIQ-LUTS-QoL scores six months after the injection. BoNT/A treatment contributed to improvements in all parameters except the average flow rate. Wild-type homozygotes (TT, n = 137) differed from TA heterozygotes (n = 19) solely in terms of pretreatment ICIQ-OAB Part A and ICIQ-LUTS-QoL Part A scores, both of which were higher in the heterozygotes. Thus, the HECTD2:rs12249854 polymorphism does not appear to be associated with the response to BoNT/A treatment. Patients with neurogenic OAB (n = 60) had a higher pretreatment detrusor pressure at maximum flow than those with idiopathic OAB (n = 96), but this difference was no longer observed after BoNT/A treatment. Good responders to the BoNT/A injection (defined as at least 50% decrease in the ICIQ-LUTS-QoL Part A score, n = 50) had a higher body mass index and parity and a lower pretreatment maximum flow rate than poor responders (n = 106). Before formulating any definitive conclusions, the results of this exploratory study should be verified in an adequately powered multicenter cohort.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland",
    "Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-204 Szczecin, Poland",
    "Department of Pharmacology and Toxicology, University of Zielona Góra, 65-417 Zielona Góra, Poland",
    "Department of Gynecology, Evangelisches Krankenhaus Hagen, 58135 Hagen, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sylwester Michał Ciećwież",
      "orcid": "0000-0002-9586-5810"
    },
    {
      "affs": [
        1
      ],
      "name": "Klaudyna Lewandowska"
    },
    {
      "affs": [
        1
      ],
      "name": "Agnieszka Boroń",
      "orcid": "0000-0003-3574-5726"
    },
    {
      "affs": [
        2
      ],
      "name": "Dariusz Kotlęga",
      "orcid": "0000-0002-3116-9656"
    },
    {
      "affs": [
        3
      ],
      "name": "Jacek Kociszewski",
      "orcid": "0000-0001-9323-9333"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrzej Ciechanowicz",
      "orcid": "0000-0002-3804-440X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dq5w2skv21yha.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219571",
  "fulltext_url": null,
  "id": "dq5w2skv21yha",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9571",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2748|Urinary Bladder and Prostate Research"
    ]
  ],
  "openalex": "W7223796452",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/dq5w2skv21yha.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27219571",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9571"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Urinary Bladder and Prostate Research",
      "subfield": "general"
    }
  ],
  "title": "Effect of the rs12249854 Polymorphism in the HECTD2 Gene and Selected Clinical Variables on the Response to Intradetrusor Injection of Botulinum Neurotoxin Type A in Female Patients with Overactive Bladder: A Single-Center Prospective Study",
  "title_text": "Effect of the rs12249854 Polymorphism in the HECTD2 Gene and Selected Clinical Variables on the Response to Intradetrusor Injection of Botulinum Neurotoxin Type A in Female Patients with Overactive Bladder: A Single-Center Prospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/dq5w2skv21yha",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}