{
  "abstract": "PAT-1, encoded by the gene SLC26A6, is an exchanger of small organic and inorganic anions including oxalate and chloride in the kidney and the intestines. PAT-1 dysfunction is implicated in nephrolithiasis and hyperoxaluria, and its modulation is a potential therapeutic strategy to treat cystic fibrosis. PAT-1 has two small molecule inhibitors: DIDS, a non-specific anion exchanger inhibitor; and PAT1inh-B01 which is highly specific to PAT-1. In this study, we report high-resolution cryo-electron microscopy structures of the human PAT-1 homodimer in complex with these inhibitors to reveal their different inhibition mechanisms. These structures also uncover the complex interactions between the transmembrane, STAS and N-terminal domains, with implications on its ion exchange function. Hence, this study provides mechanistic insight into PAT-1 molecular function and inhibition, and contributes to our understanding of SLC26 transport mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "University of Oxford"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "G. Chi"
    },
    {
      "name": "T. Bohstedt"
    },
    {
      "name": "R. Adamson"
    },
    {
      "name": "A. C. W. Pike"
    },
    {
      "name": "L. Shrestha"
    },
    {
      "name": "O. Cil"
    },
    {
      "name": "M. O. Anderson"
    },
    {
      "name": "M. Izadiar"
    },
    {
      "name": "E. Williams"
    },
    {
      "name": "N. A. Burgess-Brown"
    },
    {
      "name": "J. M. Elkins"
    },
    {
      "name": "K. L. Duerr"
    },
    {
      "name": "D. B. Sauer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dqrb03ymswvye.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.01.757131",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.757131v1.full",
  "id": "dqrb03ymswvye",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.757131v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.757131v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dqrb03ymswvye.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:30Z",
      "native_id": "10.64898/2026.11.01.757131",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.757131v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biochemistry",
      "subfield": "general"
    }
  ],
  "title": "Structural Basis for Inhibition of Human Anion Transporter SLC26A6/PAT-1",
  "title_text": "Structural Basis for Inhibition of Human Anion Transporter SLC26A6/PAT-1",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:52Z",
  "url": "https://research.draconitic.com/paper/dqrb03ymswvye",
  "venue": "bioRxiv",
  "versions": []
}