{
  "abstract": "Diaryl-substituted pyrrolidine derivatives are prevalent in numerous biologically active compounds and represent important scaffolds in medicinal chemistry. However, their synthesis remains challenging due to limitations associated with direct functionalization of the pyrrolidine ring. This work describes a facile synthesis of 1,4-diaryl-substituted pyrrolidine derivatives via Ugi multicomponent coupling reaction. The strategy enables the convergent assembly of highly functionalized pyrrolidine frameworks from readily available aromatic building blocks, thereby providing an effective alternative to conventional functionalization approaches. The operational simplicity and modularity of this method offer a practical and versatile route to pyrrolidine scaffolds of relevance to both synthetic and medicinal chemistry.",
  "abstract_shown": true,
  "affiliations": [
    "Syngene International Limited Biocon Park, Bommasandra IV Phase, Jigani Link Road Bangalore 560099 Karnataka India.",
    "Department of Chemistry, REVA University Kattigenahalli, Yelahanka Bangalore 560064 Karnataka India.",
    "School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus Clappana Kollam 690525 Kerala India vn74nr@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Siva Krishna Polineni",
      "orcid": "0009-0009-6487-5686"
    },
    {
      "affs": [
        0
      ],
      "name": "P Sathya Shanker",
      "orcid": "0009-0000-4016-9669"
    },
    {
      "affs": [
        0
      ],
      "name": "Tony Kurissery Anthappan",
      "orcid": "0009-0001-1175-3425"
    },
    {
      "affs": [
        2
      ],
      "name": "Vipin A Nair",
      "orcid": "0000-0001-7018-6451"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dqsj9d7jfkj9n.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07669f",
  "fulltext_url": "https://europepmc.org/articles/PMC13639724",
  "id": "dqsj9d7jfkj9n",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42840431",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Multicomponent Synthesis of Heterocycles"
    ]
  ],
  "openalex": "W7220650894",
  "pdf_url": "https://europepmc.org/articles/PMC13639724?pdf=render",
  "pmcid": "PMC13639724",
  "pmid": "42840431",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dqsj9d7jfkj9n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "MED:42840431",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42840431"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Multicomponent Synthesis of Heterocycles",
      "subfield": "organic"
    }
  ],
  "title": "Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction.",
  "title_text": "Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:03Z",
  "url": "https://research.draconitic.com/paper/dqsj9d7jfkj9n",
  "venue": "RSC advances",
  "versions": []
}