{
  "abstract": "Introduction\n\nWe evaluated a multimodal magnetic resonance imaging (MRI)-derived glymphatic-related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults.Methods\n\nNinety-two participants were included in the baseline analyses and 68 in the 6-month reassessment analyses. Cardiovascular risk was estimated using the Prediction for ASCVD Risk in China 10-year atherosclerotic cardiovascular disease score. The glymphatic-related composite integrated six MRI-derived measures: choroid plexus volume, choroid plexus free-water fraction, diffusion tensor image analysis along the perivascular space index, blood oxygen level-dependent signal-cerebrospinal fluid coupling, basal ganglia perivascular spaces, and deep white matter perivascular spaces. Outcomes included cortical thickness in Alzheimer's disease (AD)-vulnerable regions, peak width of skeletonized mean diffusivity, and cognitive performance.Results\n\nHigher cardiovascular risk was associated with lower glymphatic-related composite scores and lower cortical thickness in AD-vulnerable regions at baseline and the 6-month reassessment. Higher cardiovascular risk was also indirectly associated with poorer flanker task performance through the glymphatic-related composite at both assessments.Discussion\n\nThe MRI-derived glymphatic-related composite showed consistent associations with cardiovascular risk and cognitive vulnerability across repeated assessments and may serve as a summary measure of glymphatic-related MRI features in older adults.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Psychology, Southwest University, Chongqing, China.",
    "State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.",
    "Department of Neurology, University-Town Hospital of Chongqing Medical University, Chongqing, China.",
    "Chongqing Medical University, Chongqing, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Guojun Lin"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Fang Fang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Yu",
      "orcid": "0000-0003-2485-2286"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/drj1bj8n1zz0a.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71961",
  "fulltext_url": "https://europepmc.org/articles/PMC13724210",
  "id": "drj1bj8n1zz0a",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://europepmc.org/article/MED/42967579",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2804|Cerebrospinal fluid and hydrocephalus"
    ]
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  "openalex": "W7225049195",
  "pdf_url": "https://europepmc.org/articles/PMC13724210?pdf=render",
  "pmcid": "PMC13724210",
  "pmid": "42967579",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/drj1bj8n1zz0a.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967579",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967579"
    },
    {
      "first_seen": "2026-11-04T12:22:42Z",
      "native_id": "PMC13724210",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71961"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Cerebrospinal fluid and hydrocephalus",
      "subfield": "neuroscience"
    }
  ],
  "title": "MRI-derived glymphatic-related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults.",
  "title_text": "MRI-derived glymphatic-related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:53Z",
  "url": "https://research.draconitic.com/paper/drj1bj8n1zz0a",
  "venue": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
  "versions": []
}